MECT联合阿立哌唑治疗精神分裂症的效果及对MBP、GDNF和炎症因子的影响

Effect of MECT Combined with Aripiprazole in the Treatment of Schizophrenia and Its Influence on MBP,GDNF and Inflammatory Factors

目的:探讨无抽搐电休克治疗(MECT)联合阿立哌唑治疗精神分裂症的效果及对髓鞘碱性蛋白(MBP)、胶质细胞源性神经营养因子(GDNF)和炎症因子的影响。方法:选取2020年1月—2022年12月咸宁博德精神病医院收治的100例精神分裂症患者。根据随机数表法将其分为观察组与对照组,各50例。对照组给予阿立哌唑治疗,观察组在对照组基础上给予MECT治疗。比较两组治疗前后精神分裂症症状、相关指标、炎症因子,临床疗效及不良反应。结果:治疗后,两组阴性症状、阳性症状、一般精神病理症状评分及总分显著降低,观察组阴性症状、阳性症状评分及总分均显著低于对照组,差异有统计学意义(P<0.05)。观察组总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后,两组MBP水平显著降低,GDNF水平显著增高,观察组MBP水平低于对照组,GDNF水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)水平显著降低,观察组TNF-α、IL-1β均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:MECT联合阿立哌唑治疗精神分裂症能够更好地调节MBP、GDNF表达和炎症反应,改善患者精神症状,提高临床疗效,且不增加不良反应。

Objective:To investigate the effect of modified electroconvulsive therapy(MECT)combined with Aripiprazole in the treatment of schizophrenia and its influence on myelin basic protein(MBP)and glial derived neurotrophic factor(GDNF)and inflammatory factors.Method:A total of 100 patients with schizophrenia admitted to Xianning Bode Psychiatric Hospital from January 2020 to December 2022 were selected.They were divided into observation group and control group according to random number table method,with 50 cases in each group.The control group was treated with Aripiprazole,and the observation group was treated with MECT based on the control group.The symptoms of schizophrenia,related indicators,inflammatory factors before and after treatment,clinical efficacy and adverse reactions were compared between the two groups.Result:After treatment,the negative symptoms,positive symptoms,general psychopathological symptoms scores and total scores of the two groups were significantly reduced,and the negative symptoms,positive symptoms scores and total scores of the observation group were significantly lower than those of the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,MBP level was significantly decreased and GDNF level was significantly increased in both groups,MBP level in observation group was lower than that in control group,GDNF level was higher than control that in control group,the differences were statistically significant(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)in the two groups were significantly decreased,and the levels of TNF-αand IL-1βin observation group were lower than those in control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:In the treatment of schizophrenia,MECT combined with Aripiprazole can better regulate the expression of MBP,GDNF and inflammatory response,improve patients'mental symptoms,improve clinical efficacy,and do not increase adverse reactions.