不同时间服药对蒙古族、汉族非杓型高血压患者的影响

The effect of taking medication at different times on Mongolian and Han patients with non-dipping hypertension

目的探讨不同时间服用苯磺酸氨氯地平片对蒙古族、汉族非杓型高血压患者的血压影响。方法选取2022年9月至2023年9月内蒙古科技大学包头医学院第二附属医院收治的定居于内蒙古自治区且三代内没有与其他民族通婚的蒙古族非杓型高血压患者68例及汉族非杓型高血压患者70例作为研究对象。根据简单随机化法平均分为晚饭后服药组(A组)和睡前服药组(B组),两组患者均于晨起服用厄贝沙坦75mg/次,1次/d;之后A组于晚饭后加服苯磺酸氨氯地平片5mg/次,1次/d,B组于睡前加服。治疗6个月后,比较两组患者、汉族患者、蒙古族患者治疗前后的动态血压参数及两组间患者治疗后杓型血压的有效率及治疗后血压达标率。结果①动态血压指标:治疗后两组患者动态血压水平均有所下降,且A组患者指标下降较B组明显(P<0.05);汉族及蒙古族患者分别进行族群内比较,结果均与组间结果一致(P<0.05)。②非杓型血压纠正:治疗后A组患者的杓型收缩压和舒张压有效率高于B组,差异有统计学意义(P<0.05)。③血压达标率:A组患者治疗后血压达标率高于B组,差异有统计学意义(P<0.05)。结论不同时间服用苯磺酸氨氯地平对非杓型患者都有一定的治疗效果,相比之下晚饭后服药效果更好,动态血压指标改善程度、非杓型血压纠正率及血压达标率均优于睡前服药,且不论是蒙古族还是汉族非杓型高血压患者晚饭后服药效果均优于睡前服药。

Objective To investigate the effects of amlodipine benzenesulfonate tablets administered at different time points on blood pressure in Mongolian and Han patients with non-dipping hypertension.Methods A total of 68 cases of Mongolian with non-dipping hypertension who had settled in Inner Mongolia and had not intermarried with other nationalities within three generations and 70 cases of Han patients with non-dipping hypertension were consecutively selected as research object,they all received diagnosis at the Second Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from September 2022 to September 2023,and were divided into two groups on average according to the simple randomization method,the group of medication after dinner(group A)and the group of medication before bedtime(group B),and both groups took irbesartan 75mg in the morning,once a day.After that amlodipine benzenesulfonate tablets 5mg,once a day,were added after dinner in group A and before bedtime in group B.Treatment was carried out for 6 months.The ambulatory blood pressure parameters of total patients,Han patients and Mongolian patients before and after treatment were compared between two groups,as well as the proportion of nonpareil blood pressure and the blood pressure compliance rate of total patients after treatment between two groups.Results①Dynamic blood pressure indicators:After treatment,the dynamic blood pressure levels in both groups of patients decreased,and the decrease in indicators in group A was more significant than that in group B(P<0.05);Han and Mongolian patients were compared within their respective populations,and the results were consistent with the inter group comparison of the total patients(P<0.05).②Correction of non dipper blood pressure:After treatment,the effective rates of dipper blood pressure in group A were higher than those in group B,and the difference was statistically significant(P<0.05).③Blood pressure compliance rate:The blood pressure compliance rate of group A patients after treatment was higher than that of group B,and the difference was statistically significant(P<0.05).Conclusion Amlodipine benzenesulfonate taken at different times has certain therapeutic effects on patients with non-dipping hypertension,and therapeutic effects are better compared with the effect of patients taking the drug after dinner,the degree of improvement of ambulatory blood pressure indexes,correction rate of non-dipping hypertension and blood pressure compliance rate are better than those of patients who take the drug before bedtime,and the effect of taking the drug after dinner is better than that take the drug before bedtime for both Mongolian and Han patients with non-dipping hypertension.