TLR4/NF-κB信号通路对骨骼肌纤维化的调节研究进展

Research progress of TLR4/NF-κ B signaling pathway on skeletal muscle fibrosis

骨骼肌纤维化导致了肌肉结构的改变,并干扰肌纤维的再生及收缩功能的恢复,最终损害肌纤维功能,促进疾病的发生、发展,影响患者的生命和生活质量。在此过程中,Toll样受体4(TLR4)及其下游效应因子核转录因子-κB(NF-κB)已被证实可以促进胶原蛋白的生成及组织纤维化的发生。本文就TLR4/NF-κB信号通路对骨骼肌纤维化的调节进行综述。

Skeletal muscle fibrosis changes muscle structure and interferes with the regeneration of muscle fibers and the recovery of contraction function,ultimately damaging muscle fiber function,promoting the occurrence and development of diseases,and affecting the quality of life of patients.During this process,Toll-like receptor 4(TLR4)and its downstream effector,nuclear factor kappa B(NF-κ B)have been shown to promote collagen production and tissue fibrosis.This article reviews the regulation of skeletal muscle fibrosis by the TLR4/NF-κ B signaling pathway.