Stevens-Johnson综合征及中毒性表皮坏死松解症的早期眼部诊疗管理

The early ophthalmic diagnosis and treatment of Stevens-Johnson syndrome and toxic epidermal necrolysis

Stevens-Johnson综合征(Stevens-Johnson syndrome,SJS)和中毒性表皮坏死松解症(toxic epidermal necrolysis,TEN)是由药物引发的罕见但极为严重的皮肤黏膜疾病,常伴随眼部的急慢性并发症,甚至导致失明,严重影响患者的生活质量。急性期患者的眼部受累率很高,但对眼部状况的重视程度尚不够。早期诊断和积极强化的抗炎治疗甚至羊膜移植,对减缓损伤进展、防止晚期严重并发症的发生、改善患者生活质量至关重要。本文强调了SJS-TEN早期眼部诊疗的重要性,旨在提高对其眼部并发症的认识,促进更加积极明确的早期诊断和治疗,以降低视力损伤风险,提升患者远期生活质量。

Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare yet severe drug-induced mucocutaneous conditions,frequently presenting with acute and chronic ocular complications.Severe cases can result in blindness.The incidence of ocular involvement is high in patients during the acute phase,yet ocular conditions are often overlooked.Early diagnosis and aggressive anti-inflammatory treatment,including amniotic membrane transplantation,are crucial to mitigate damage and prevent severe late-stage complications,and enhance the quality of life for patients.This paper emphasizes the importance of early ophthalmic management in SJS-TEN,aiming to raise awareness of ocular complications,promote early diagnosis and intervention,reduce vision loss risk,and improve the long-term quality of life for patients.