乳糜泻患者消化道不同部位的微生物多样性

Microbial diversity in different parts of the digestive tract in celiac disease

乳糜泻(celiac disease,CD)是一种由遗传易感个体摄入麸质蛋白后引起的小肠自身免疫性疾病。微生态失调可能导致消化道内病原微生物感染,引起肠道持续性炎症,从而破坏肠道免疫稳态,参与CD的病理生理过程。消化道不同部位功能的异质性可导致肠道微生物的区域差异。由于肠道微生物的组成在很大程度上取决于采样部位,本文将从CD与消化道不同部位微生物群、无麸质饮食治疗后消化道不同部位微生物群和真菌群的关系3个方面,阐述消化道不同部位微生态失调与CD的关系,从而促进以微生物为靶点防治CD策略的开发。

Celiac disease(CD)is an autoimmune disease of the small intestine caused by the ingestion of gluten protein in genetically susceptible individuals.Microecological imbalance may lead to the infection by pathogenic microorganisms in the digestive tract,which cause persistent intestinal inflammation,disrupting intestinal immune homeostasis and participating in the pathophysiological process of CD.The functional heterogeneity of different parts of the digestive tract can lead to regional differences in intestinal microbes.Since the composition of intestinal microorganisms depends largely on the sampling site,this article will review the relationship between the microecological imbalance in different parts of the digestive tract and CD from three aspects:the microbiota in different parts of the digestive tract,the changes of microbiota in different parts of the digestive tract after gluten-free diet treatment,and the relationship between CD and fungal microbiota,in order to help promoting the development of microorganism-targeting strategies for CD prevention and treatment.