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污水流行病学在毒情监测中的不确定性-以甲基苯丙胺为例

Uncertainties of illicit drugs consumption estimated by wastewaterbased epidemiology:The case of methamphetamine
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摘要 污水流行病学在毒情监测评估中发挥的作用日趋显著,但在实战应用中仍存在一些亟待研究解决的问题,突出体现为监测结果的不确定性.本文首次以国内滥用最为严重的甲基苯丙胺为切入点,结合近年来文献中有关参数的采用情况,对采样、仪器分析和计算过程中可能引起毒情评估偏差的因素进行全面比对分析.同时,指出今后研究的重点方向,以期进一步提高基于污水流行病学的毒情监测工作的标准化和精准度,为相关研究工作提供参考. Wastewater-based epidemiology(WBE)plays a vital role in monitoring the pattern of consumption of illicit drugs in a general population.However,it also brings several uncertainties about the results.For the first time,the paper investigates the potential and reliability of WBE methodologies from methamphetamine,the most abused drug in China,by critically looking at the literature published in the last three years.The uncertainties related to sampling methodology,analytical procedure,and consumption calculation are analyzed in detail,and suggestions to further promote WBE studies and universal analysis criteria for valid comparisons are provided.
作者 郑晓雨 杨虹贤 闻武 杨帆 车鑫锋 赵兴春 ZHENG Xiaoyu;YANG Hongxian;WEN Wu;YANG Fan;CHE Xinfeng;ZHAO Xingchun(Key Laboratory of Drug Monitoring and Control,Drug Intelligence and Forensic Center,Ministry of Public Security,Beijing,100193,China;Institute of Forensic Science of China,Ministry of Public Security,Beijing,100038,China;China Pharmaceutical University,Nanjing,210009,China)
出处 《环境化学》 CAS CSCD 北大核心 2024年第7期2260-2268,共9页 Environmental Chemistry
基金 国家自然科学基金(21806022) 中央级科研院所基本科研业务费(2018JB042)资助.
关键词 污水分析 甲基苯丙胺 不确定性 禁毒 wastewater analysis methamphetamine uncertainty anti-drugs
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