非酒精性脂肪性肝病中miRNA的功能及临床研究进展

Advances in the function and clinical study of miRNA in nonalcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)目前已成为导致慢性肝病的最重要病因,其致病机制十分复杂。微小核糖核酸(miRNA)是分布十分广泛的非编码RNA,miRNA在包括NAFLD在内的多种慢性肝病的致病及进展中发挥着重要的调控作用,甚至可能作为肝脏疾病的诊断指标甚至治疗靶点。作为无创生物学指标,大量的研究数据显示miRNA在NAFLD的诊断及预后中有重要临床价值。该文针对miRNA在NAFLD中的致病机制及临床诊疗价值的相关研究进展做一综述。

Non-alcoholic fatty liver disease(NAFLD)has become the most important cause of chronic liver disease,and its pathogenic mechanism is very complex.microRNA(miRNA)are widely distributed non-coding RNA.miRNA play an important regulatory role in the pathogenesis and progression of various chronic liver diseases,including NAFLD,and may even be used as diagnostic indicators or even therapeutic targets for liver diseases.As a non-invasive biological indicator,a large number of research data show that miRNA has important clinical value in the diagnosis and prognosis of NAFLD.This article provides a review of the research progress related to the pathogenic mechanism and clinical diagnostic value of miRNA in NAFLD.