通关藤注射液联合SOX方案治疗进展期胃癌临床观察

Clinical Effect of Tongguanteng Injection Combined with the SOX Regimen in Treatment of Advanced Gastric Cancer

目的观察通关藤注射液联合SOX方案治疗进展期胃癌的疗效。方法将60例进展期胃癌患者随机分为对照组和观察组,每组30例。对照组患者接受标准SOX方案化学治疗;观察组患者加用通关藤注射液治疗。治疗前后分别检测患者血清癌胚抗原(carcinoembryonic antigen,CEA)、糖类抗原(carbohydrate antigen,CA)125、CA153、CA199水平,以及肝肾功能和血清白蛋白,并检测血小板、淋巴细胞、中性粒细胞、单核细胞计数及中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet-to-lymphocyte ratio,PLR),采用卡氏功能状态量表(Karnofsky’s performance status,KPS)评价患者生活质量,比较两组患者总生存期(overall survival,OS)和无进展生存期(progression-free survival,PFS)。结果观察组在降低血清CA125、CA199、PLR水平,提高KPS评分,防止血清白蛋白和淋巴细胞水平降低,延长OS和PFS方面均显著优于对照组(P<0.05)。结论通关藤注射液联合SOX方案治疗进展期胃癌具有增效减毒作用,可降低化学治疗药物不良反应,延长患者生存期。

Objective To investigate the efficacy of Tongguanteng Injection combined with the SOX regimen in the treatment of advanced gastric cancer.Methods A total of 60 patients with advanced gastric cancer were randomly divided into control group and observation group,with 30 patients in each group.The patients in the control group received standard chemotherapy with the SOX regimen,while those in the observation group received Tongguanteng Injection in addition to the SOX regimen.Related indicators were measured before and after treatment,including the serum levels of carcinoembryonic antigen,carbohydrate antigen 125(CA125),carbohydrate antigen 153,and carbohydrate antigen 199(CA199),liver and renal function,serum albumin,platelet count,lymphocytes,neutrophils,monocytes,neutrophil-to-lymphocyte ratio,and platelet-to-lymphocyte ratio(PLR).Karnofsky’s Performance Scale(KPS)was used to evaluate quality of life,and the two groups were compared in terms of overall survival(OS)and progression-free survival(PFS).Results Compared with the control group,the observation group had significant reductions in the serum levels of CA125,CA199,and PLR and a significant increase in KPS score,as well as significantly better results in preventing the reductions in serum albumin and lymphocytes and prolonging OS and PFS(P<0.05).Conclusion Tongguanteng Injection combined with the SOX regimen can effectively enhance therapeutic efficacy and reduce toxicity in the treatment of advanced gastric cancer,and it can also reduce the adverse reactions caused by chemotherapy drugs and prolong the survival of patients.