防风通圣散联合微针导入米诺地尔治疗脾胃湿热型雄激素性脱发临床观察

Clinical Effect of Fangfeng Tongsheng Powder Combined with Microneedle Induction of Minoxidil in Treatment of Androgenic Alopecia with Spleen-Stomach Damp-Heat Syndrome

目的观察防风通圣散加减方联合微针导入米诺地尔治疗脾胃湿热型雄激素性脱发的临床疗效。方法将60例脾胃湿热型雄激素性脱发患者随机分为对照组和治疗组,每组30例。对照组患者接受微针导入米诺地尔治疗,治疗组患者在对照组基础上口服防风通圣散加减方。观察并比较两组治疗前后脱发症状、脾胃湿热症状、皮肤镜下毛发相关指标、脂质代谢水平及不良反应发生情况。结果在提高皮肤镜下每平方厘米毛发数、直立再生毛发数,降低皮肤镜下毳毛数、单一毛囊单位数和褐色毛周征数方面,以及在降低脱发、头皮瘙痒、头发油腻、头屑、新发不生症状积分方面,治疗组显著优于对照组(P<0.05);与治疗前比较,治疗组治疗后口干口苦、纳呆、便溏、身重乏力积分和血清总胆固醇、低密度脂蛋白胆固醇水平显著降低(P<0.05),血清高密度脂蛋白胆固醇水平显著升高(P<0.05),而对照组治疗后上述指标无明显改善(P>0.05)。两组不良反应发生率比较,差异无统计学意义善(P>0.05)。结论防风通圣散加减方联合微针导入米诺地尔治疗脾胃湿热型雄激素性脱发疗效确切,安全性较好。

Objective To investigate the clinical effect of Fangfeng Tongsheng Powder combined with microneedle induction of minoxidil in the treatment of androgenic alopecia with spleen-stomach damp-heat syndrome. Methods A total of 60 patients with androgenic alopecia with spleen-stomach damp-heat syndrome were randomly divided into control group and treatment group,with 30 patients in each group.The patients in the control group received microneedle induction of minoxidil,while those in the treatment group received oral administration of modified Fangfeng Tongsheng Powder in addition to the treatment in the control group.Before and after treatment,the two groups were observed and compared in terms of alopecia symptoms,spleen-stomach damp-heat symptoms,hair-related indices under dermoscopy,lipid metabolism levels,and adverse reactions. Results After treatment,compared with the control group,the treatment group had significantly better improvements in hair density and number of erect regenerated hairs and significant reductions in the number of pilosebaceous hairs,the number of single hair follicle units,and brown hair circumference sign under dermoscopy,as well as significant reductions in the scores of alopecia,scalp pruritus,greasy hair,dandruff,and absence of new hair(P<0.05).After treatment,the treatment group had significant reductions in the scores of dry mouth/bitter taste,poor appetite,loose stool,and weakness and the serum levels of total cholesterol and low-density lipoprotein cholesterol(P<0.05),as well as a significant increase in the serum level of high-density lipoprotein(P<0.05),while the control group showed no significant improvements in the above indicators after treatment(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Modified Fangfeng Tongsheng Powder combined with microneedle induction of minoxidil has a marked clinical effect in the treatment of androgenic alopecia with spleen-stomach damp-heat syndrome,with a favorable safety profile.