脂肪移植后脂肪细胞和巨噬细胞的脂质代谢

Lipid metabolism of adipocytes and macrophages after fat grafting

脂肪移植后存活率难以预测,并可能出现相关并发症,如油囊肿形成、脂肪坏死,主要原因在于脂肪移植过程中脂肪细胞被破坏,移植后脂肪细胞坏死而释放大量的油滴。了解脂肪移植后移植物的脂质代谢,包括细胞内的脂质代谢和细胞外的油滴代谢,对提高脂肪移植存活率和减少并发症具有重要意义。该文主要介绍了脂肪细胞和巨噬细胞在生理状态下和脂肪移植后炎症状态下的脂质代谢和相关的免疫调控,并阐述了脂肪移植物代谢和宿主整体脂质代谢之间的相互调节关系。

The survival rate of fat grafts is challenging to predict,and related complications such as oil cyst formation and fat necrosis may occur.The primary cause is that adipocytes are destroyed during fat grafting,and adipocyte necrosis releases a large number of oil droplets.Understanding the lipid metabolism of fat grafts,including intracellular lipid metabolism and extracellular oil droplet metabolism,is crucial to improve the survival rate of fat grafts and reduce complications.This article primarily explored the lipid metabolism and associated immune regulation of adipocytes and macrophages under both physiological and inflammatory conditions after fat grafting,and explained the mutual regulatory relationship between fat graft metabolism and the host’s overall lipid metabolism.