芍药汤加味联合洛哌丁胺治疗免疫相关性结肠炎33例疗效观察

Clinical Efficacy of Supplemented Shaoyao Decoction Combined with Loperamide in Treatment of 33 Cases of Immune-Associated Colitis

目的:观察分析采用芍药汤加味联合洛哌丁胺口服治疗免疫相关性结肠炎的临床效果。方法:选取2020年1月至2023年8月,本院收治的66例免疫相关性结肠炎患者,采用随机数字法分为观察组和对照组,每组各33例。对照组采用洛哌丁胺口服治疗,观察组在此基础上联合芍药汤加味口服。对比2组临床疗效及中医证候积分情况。结果:治疗后5d和7d,观察组总有效率分别为78.79%和93.94%,高于对照组的54.55%和75.76%(P<0.05),且肛门灼痛、腹痛腹泻、泻下急迫及里急后重各中医证候积分均低于对照组(P<0.05)。结论:采用芍药汤加味联合洛哌丁胺口服治疗免疫相关性结肠炎,可有效控制病情,避免疾病持续进展,并能改善临床各项指标,疗效确切。

Objective To observe the clinical effect of supplemented Shaoyao Decoction combined with Loperamide in the treatment of immune-associated colitis.Methods A total of 66 patients with im-mune-associated colitis admitted to our hospital from January 2020 to August 2023 were selected and di-vided into observation group and control group by random number method,with 33 cases in each group.The control group was treated with Loperamide orally,while the observation group was treated with sup-plemented Shaoyao Decoction orally in addition.The clinical efficacy and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups.Results On the 5th and 7th day after treatment,the total effective rate was 78.79%and 93.94%respectively in the observation group,which was higher than 54.55%and 75.76%in the control group(P<0.05),and the TCM syndrome scores of anal burning pain,abdominal pain and diarrhea,urgent diarrhea and tenesmus were lower than those of the control group(P<0.05).Conclusion The oral medication of supplemented Shaoyao Decoction combined with Loperamide in the treatment of immune-associated colitis can effectively control the condi-tion,prevent progression of the disease,and improve clinical indicators,with accurate efficacy.