直肠癌患者新辅助放疗敏感性的影响因素

Influencing Factors of Neoadjuvant Radiotherapy Sensitivity in Patients with Rectal Cancer

目的分析直肠癌患者新辅助放疗敏感性的影响因素。方法选取接受新辅助放疗的60例直肠癌患者,采用直肠癌消退分级(RCRG)评估患者对新辅助放疗的敏感性,并按照其放疗敏感性分为敏感组(n=28)与不敏感组(n=32)。比较2组患者核基质结合区结合蛋白1(SATB1)表达强度及临床病理特征间的差异。应用Logistic回归分析直肠癌新辅助放疗不敏感的独立影响因素。结果2组患者间年龄、性别、神经侵犯、肿瘤分期比较,差异无统计学意义(P>0.05);2组患者肿瘤分化程度、肿瘤浸润深度、淋巴结转移情况、肿瘤侵犯管腔周径、SATB1表达强度比较,差异有统计学意义(P<0.05)。Logistic回归分析发现,SATB1高表达、有淋巴结转移是直肠癌新辅助放疗不敏感的独立影响因素(P<0.05)。结论对新辅助放疗敏感性不同的直肠癌患者在肿瘤分化程度、肿瘤浸润程度、合并淋巴结、肿瘤侵犯管腔周径、SATB1表达强度方面均存在差异,SATB1高表达、有淋巴结转移是直肠癌新辅助放疗不敏感的独立影响因素。

Objective To analyze the influencing factors of neoadjuvant radiotherapy sensitivity in patients with rectal cancer.Methods A total of 60 patients with rectal cancer underwent neoadjuvant radiotherapy were enrolled.According to radiotherapy sensitivity by rectal cancer regression grading(RCRG),patients were divided into sensitivity group(n=28)and non-sensitivity group(n=32).The differences in expression intensity of special AT rich sequence binding protein(SATB1)and clinicopathological characteristics were compared between the 2 groups.The independent risk factors of neoadjuvant radiotherapy non-sensitivity in rectal cancer were analyzed by Logistic regression analysis.Results There was no significant difference in age,genders,nerve invasion or tumor staging between the 2 groups(P>0.05),but there were significant differences in tumor differentiation degree,depth of tumor invasion,lymph node metastasis,diameter of tumor invasion lumen and expression intensity of SATB1 between the 2 groups(P<0.05).Logistic regression analysis showed that high expression of SATB1 and lymph node metastasis were independent influencing factors of neoadjuvant radiotherapy non-sensitivity in rectal cancer(P<0.05).Conclusion There are differences in tumor differentiation degree,tumor invasion degree,lymph node metastasis,diameter of tumor invasion lumen and expression intensity of SATB1 in rectal cancer patients with different neoadjuvant radiotherapy sensitivity.High expression of SATB1 and lymph node metastasis are independent influencing factors of neoadjuvant radiotherapy non-sensitivity in rectal cance.