线粒体呼吸链酶复合物在心肌缺血再灌注损伤中的作用进展

Advances in the role of mitochondrial respiratory chain enzyme complexes in myocardial ischemiareperfusion injury

心肌缺血再灌注损伤(myocardial ischemia reperfusion injury,MIRI)是一种常见的心血管并发症,是困扰众多临床学者的一大难题。为改善MIRI预后众多学者致力于其机制的研究,发现线粒体与MIRI的发生密切相关,其中线粒体呼吸链酶复合物功能受损,能量代谢障碍在MIRI的发生过程中起着关键作用。本综述旨在阐述MIRI中线粒体呼吸链酶复合物的变化及其对MIRI的影响,为MIRI寻找新的有效治疗靶点提供依据。

Myocardial ischemia reperfusion injury(MIRI)is a common cardiovascular complications,which is a major problem for many clinical scholars.To improve the prognosis of MIRI,many scholars have devoted to the research of its mechanism,and founded that mitochondria are closely related to the occurrence of MIRI,where the function of mitochondrial respiratory chain enzyme complex is impaired,and energy metabolism disorders play a key role in the process of MIRI.The aim of this review is to describe the changes of mitochondrial respiratory chain enzyme complex in MIRI and its effect on MIRI,and to provide a basis for finding new and effective therapeutic targets for MIRI.