夹脊通督针刺疗法联合柴胡桂枝干姜汤对胃食管反流患者胃肠功能及血清炎症因子水平的影响

Effects of Jiaji Tongdu acupuncture therapy combined with Chaihu Guizhi Ganjiang Decoction on gastrointestinal function and serum inflammatory factors in patients with gastroesophageal reflux

目的:观察夹脊通督针刺疗法联合柴胡桂枝干姜汤在胃食管反流(GERD)治疗中的应用价值,分析其对胃肠功能、炎症因子水平的影响。方法:回顾性选取2021年6月—2023年6月本院收治的96例GERD患者为研究对象,依据治疗方案不同分为汤剂组32例、针刺组32例、联合组32例。汤剂组予以柴胡桂枝干姜汤治疗,针刺组予以夹脊通督针刺疗法治疗,联合组予以夹脊通督针刺疗法联合柴胡桂枝干姜汤治疗。比较3组临床疗效、安全性及治疗前后中医证候积分、胃肠功能[胃泌素(GAS)、胆囊收缩素(CCK)、胃动素(MTL)]、炎症因子[白细胞介素-8(IL-8)、P物质(SP)、内皮素-1(ET-1)]、氧化应激[超氧化物歧化酶(SOD)、脂质过氧化物(LPO)]水平。结果:联合组总有效率高于汤剂组、针刺组(P<0.05),汤剂组与针刺组比较无明显差异(P>0.05);治疗后,联合组中医证候积分低于汤剂组、针刺组(P<0.05);治疗后,联合组血清GAS、MTL、SOD水平高于汤剂组、针刺组,CCK、IL-8、SP、ET-1、LPO水平低于汤剂组、针刺组(P<0.05);3组不良反应发生率比较无明显差异(P>0.05)。结论:夹脊通督针刺疗法联合柴胡桂枝干姜汤治疗GERD的疗效显著,可改善临床症状,促进胃肠功能恢复,且安全性良好,可能与调节炎症-氧化应激反应有关。

Objective:To observe the application value of Jiaji Tongdu acupuncture therapy combined with Chaihu Guizhi Ganjiang Decoction in the treatment of gastroesophageal reflux disease(GERD),and analyze its effects on gastrointestinal function and levels of inflammatory factors.Methods:A total of 96 GERD patients admitted to our hospital from June 2021 to June 2023 were retrospectively selected as the study objects,and were divided into decoction group(32 cases),acupuncture group(32 cases)and combination group(32 cases)according to different treatment plans.The decoction group was treated with Chaihu Guizhi Ganjiang decoction,the acupuncture group was treated with Jiaji Tongdu acupuncture,and the combined group was treated with Jiaji Tongdu acupuncture combined with Chaihu Guizhi Ganjiang decoction.Compare the clinical efficacy,safety of the two groups,as well as TCM syndrome score,gastrointestinal function[gastrin(GAS),cholecystokinin(CCK),motilin(MTL)],inflammatory factors[interleukin-8(IL-8),substance P(SP),endothelin-1(ET-1)],oxidative stress[superoxide dismutase(SOD),Lipid peroxides(LPO)]levels before and after treatment.Results:The total effective rate of combined group was higher than that of decoction group and acupuncture group(P<0.05),but there was no significant difference between decoction group and acupuncture group(P>0.05).After treatment,the TCM syndrome score of combination group was lower than that of decoction group and acupuncture group(P<0.05).After treatment,the levels of GAS,MTL and SOD in combined group were higher than those in decoction group and acupuncture group,while the levels of CCK,IL-8,SP,ET-1 and LPO in combined group were lower than those in decoction group and acupuncture group(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion:Jiaji Tongdu acupuncture therapy combined with Chaihu Guigui Zhigan Jiang Decoction has significant curative effect on GERD,can improve clinical symptoms,promote gastrointestinal function recovery,and has good safety,which may be related to regulating inflammatory and oxidative stress reaction.