AQP5调控细胞程序性死亡在慢性阻塞性肺疾病中的研究现状

Research status of AQP5 regulation of programmed cell death in chronic obstructive pulmonary disease

水通道蛋白5(AQP5)作为机体主要的水转运蛋白,可通过调控气道黏液分泌、肺部炎症、肺功能等过程来调节肺部疾病。细胞程序性死亡(PCD)在慢性阻塞性肺疾病(COPD)中发挥着至关重要的作用。AQP5可能通过调控PCDs影响着COPD发生发展。本文综述了近年来AQP5对PCDs中细胞凋亡、自噬、铁死亡、焦亡等的分子调控机制,并进一步讨论其对COPD的影响,以期为临床防治COPD提供理论支撑。

Aquaporin 5(AQP5),as the main water transport protein in the body,can regulate lung diseases by regulating airway mucus secretion,pulmonary inflammation,and lung function.Programmed cell death(PCD)plays a crucial role in chronic obstructive pulmonary disease(COPD).AQP5 may affect the development of COPD by regulating PCDs.This article reviews the molecular regulatory mechanism of AQP5 on apoptosis,autophagy,iron death and pyroptosis in PCDs in recent years,and further discusses its effect on COPD in order to provide theoretical support for clinical prevention and treatment of COPD.