青藤碱治疗阿尔茨海默病机制的研究现状

Research status on the mechanism of sinomenine in treatment of Alzheimer's disease

阿尔茨海默病(AD)是一种破坏性神经退行性疾病,可导致严重的认知障碍。青藤碱可抑制AD中星形胶质细胞的活化及其氧化应激与炎症因子水平升高、保护神经元免受星形胶质细胞间接毒性、抑制小胶质细胞介导的神经炎症、抑制乙酰胆碱酯酶、β-分泌酶1活性,进而发挥抗AD作用。本文通过对青藤碱治疗AD的分子机制进行综述,为治疗AD新药开发提供依据。

Alzheimer's disease(AD)is one kind of disruptive neurodegenerative disease which can lead to severe cognitive dysfunction.Sinomenine can inhibit the activation of astrocytes,increase of oxidative stress and levels of inflammatory factors,protect neurons from indirect toxicity of astrocytes,inhibit microglial-mediated neuroinflammation,inhibit acetyl cholinesterase andβ-site amyloid precursor protein cleaving enzyme-1 activities in AD,thus exert anti AD effects.According to review the molecular mechanisms of sinomenine in treatment of AD,we aim to provide a basis for the development of new drugs for treatment of AD.