甲状旁腺素、性激素对绝经后女性骨质疏松症的诊断价值分析

Diagnostic Value of Parathyroid Hormone and Sex Hormone in Postmenopausal Women with Osteoporosis

目的:探讨与分析甲状旁腺素、性激素对绝经后女性骨质疏松症的诊断价值.方法:选取2021年3月—2023年5月我院收治的89例绝经后女性人群作为研究对象.所有人群在入院时均给予骨密度检测与血清甲状旁腺素、性激素检测,判定受试者的骨质疏松症发生情况并进行相关性分析.结果:在89例受试者中,发生骨质疏松症19例(骨质疏松症组),占比21.3%,骨质疏松症组的股骨颈骨密度、T分数均低于非骨质疏松症组,组间差异有统计学意义(P<0.05).2组绝经年限、年龄、孕次、产次、体重指数、受教育年限比较,组间差异无统计学意义(P>0.05).骨质疏松症组的血清甲状旁腺素症、血清雌二醇、睾酮、孕酮含量均低于非骨质疏松症组,血清促卵泡激素、促黄体生成素、垂体泌乳素含量均高于非骨质疏松症组,组间差异有统计学意义(P<0.05).在89例受试者中,Spearman分析显示,骨质疏松症与血清甲状旁腺素、雌二醇、睾酮、孕酮、促卵泡激素、促黄体生成素、垂体泌乳素含量等都存在相关性(P<0.05).logistic回归分析显示,血清甲状旁腺素、雌二醇、睾酮、促卵泡激素等为导致绝经后女性骨质疏松症发生的影响因素(P<0.05).结论:绝经后女性骨质疏松症的发病率较高,多伴随有血清甲状旁腺素与性激素表达异常,甲状旁腺素、性激素与绝经后女性骨质疏松症的发生存在相关性,也具有诊断骨质疏松症的价值.

Objective:To explore and analyze the diagnostic value of parathyroid hormone and sex hormone in postmenopausal women with osteoporosis.Methods:89 postmenopausal women treated in our hospital from March 2021 to May 2023 were selected as the study objects.Bone mineral density and serum parathyroid hormone and sex hormone were detected in all patients at admission to determine the incidence of osteoporosis and conduct correlation analysis.Results:Among the 89 subjects,19 cases(osteoporosis group)developed osteoporosis,accounting for 21.3%.The bone mineral density and T score of femur neck in the osteoporosis group were lower than those in the non-osteoporosis group,and the differences between groups were statistically significant(P<0.05).There were no significant differences in menopause years,age,pregnancy times,childbirth times,body mass index and years of education between the two groups(P>0.05).The contents of serum parathyroid hormone,serum estradiol,testosterone and progesterone in osteoporosis group were lower than those in non-osteoporosis group,and the contents of serum follicle-stimulating hormone,luteinizing hormone and pituitary prolactin in the osteoporosis group were higher than those in the non-osteoporosis group,with statistical significance(P<0.05).Conclusion:Postmenopausal women have a high incidence of osteoporosis,which is often accompanied by abnormal expression of serum parathyroid hormone and sex hormone.Parathyroid hormone and sex hormone are correlated with the occurrence of postmenopausal women's osteoporosis,and have the value of diagnosing osteoporosis.