抗γ-氨基丁酸B型受体脑炎的研究进展

Research progress on antiγ-aminobutyric acid B receptor encephalitis

抗γ-氨基丁酸B型受体脑炎是自身免疫性脑炎的一种,其特征是脑脊液和(或)血清中产生自身特异性抗体,以癫痫发作、记忆力减退和意识障碍为主要临床表现。这种自身抗体导致的脑炎与其他边缘叶脑炎有相同的病理特征。诸多不同的病因和病理生理过程导致边缘叶脑炎的发生,有必要了解其中的异质性,以找到有效的治疗方法。本文将系统性回顾抗γ-氨基丁酸B型受体脑炎的流行病学、发病机制、临床特征、诊断、治疗和预后,旨在提升临床医生对本病的认识,为临床决策提供参考。

Anti-aminobutyric acid B receptor encephalitis is a type of autoimmune encephalitis characterized by the production of self specific antibodies in cerebrospinal fluid and/or serum,with seizures,memory loss,and consciousness disorders as the main clinical manifestations.This type of encephalitis caused by autoantibodies has the same pathological characteristics as other peripheral encephalitis.There are many different etiologies and pathophysiological processes that lead to the occurrence of limbic encephalitis,and it is necessary to understand their heterogeneity in order to find effective treatment methods.This article will systematically review the epidemiology,pathogenesis,clinical characteristics,diagnosis,treatment,and prognosis of anti-aminobutyric acid B receptor encephalitis,aiming to enhance clinical doctors'understanding of this disease and provide reference for clinical decision-making.