西黄丸联合地塞米松治疗浆细胞性乳腺炎的临床研究

Clinical study on Xihuang Pills combined with dexamethasone in treatment of plasma cell mastitis

目的探讨西黄丸联合地塞米松片治疗浆细胞性乳腺炎的临床疗效。方法选取2021年10月—2023年9月在邢台市中心医院接受治疗的114例浆细胞性乳腺炎患者,按随机数字表法将所有患者分为对照组和治疗,每组57例。对照组口服地塞米松片,4片/次,2次/d。治疗组在对照组基础上口服西黄丸,3 g/次,2次/d。两组患者的治疗时间1个月。比较两组的临床疗效、症状消失时间、疼痛程度、超声指标和血清指标。结果治疗后,治疗组的总有效率为92.98%,高于对照组的总有效率78.95%,差异具有有统计学意义(P<0.05)。治疗后,治疗组疼痛、红肿、肿块、乳头溢液消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,两组视觉模拟评分法(VAS)评分均显著降低(P<0.05),且治疗组的VAS评分低于对照组(P<0.05)。治疗后,两组的SR、乳腺肿块最大直径比治疗前小(P<0.05);治疗组的应变率(SR)、乳腺肿块最大直径比对照组小(P<0.05)。治疗后,两组的血清细胞间黏附分子1(ICAM-1)、Toll样受体2(TLR2)、白细胞介素-37(IL-37)水平比治疗前低(P<0.05);治疗组的血清ICAM-1、TLR2、IL-37水平比对照组小(P<0.05)。结论西黄丸联合地塞米松片可提高浆细胞性乳腺炎的疗效,改善临床症状,减轻患者疼痛程度,降低炎症反应和肿块大小。

Objective To investigate the clinical effect of Xihuang Pills combined with Dexamethasone Acetate Tablets in treatment of plasma cell mastitis.Methods Patients(114 cases)with plasma cell mastitis in Xingtai Central Hospital from October 2021 to September 2023 were divided into control and treatment groups according to the random number table method,and each group had 57 cases.Patients in the control group were po administered with Dexamethasone Acetate Tablets,4 tablets/time,twice daily.Patients in the treatment group were po administered with Xihuang Pills on the basis of the control group,3 g/time,twice daily.Patients in two groups were treated for 1 month.The clinical efficacies,the symptom disappearance time,degree of pain,ultrasound indicators,and serum indicators in two groups were compared.Results After treatment,the total effective rate of the treatment group was 92.98%,which was higher than 78.95%of the control group,and the difference was statistically significant(P<0.05).After treatment,the disappearance time of pain,redness,mass,and nipple discharge in the treatment group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,VAS score of two groups was significantly decreased(P<0.05),and VAS score of the treatment group was lower than that of the control group(P<0.05).After treatment,SR and maximum diameter of breast mass were smaller than before treatment(P<0.05),and SR and maximum diameter of breast mass in the treatment group were smaller than those in the control group(P<0.05).After treatment,the serum levels ofICAM-1,TLR2,and IL-37 in two groups were lower than those before treatment(P<0.05),and the serum levels of ICAM-1,TLR2,and IL-37 in the treatment group were lower than those in the control group(P<0.05).Conclusion Xihuang Pills combined with Dexamethasone Acetate Tablets can improve the efficacy of plasma cell mastitis,further improve the clinical symptoms,reduce the pain degree of patients,and reduce the inflammatory response and tumor size.