NETs介导类风湿性关节炎并发动脉粥样硬化及中药干预研究进展

NETs Induced Rheumatoid Arthritis with Atherosclerosis and the Intervention of Traditional Chinese Medicine

流行病学数据表明,心血管并发症困扰着近半数类风湿性关节炎(Rheumatoid arthritis,RA)患者,是RA患者的主要死亡原因。这可能与RA同动脉粥样硬化具有相似的病理特征,致使该病患者动脉粥样硬化发生率增加有关。中性粒细胞胞外诱捕网作为一把双刃剑,一方面能捕获病原体限制疾病发展,一方面也可成为致病因素加重病情,其介导的炎症反应是RA、动脉粥样硬化、血栓等疾病的共同特点。研究表明,中医药可通过多种途径对动脉粥样硬化产生积极作用,相关中药通过调控中性粒细胞胞外诱捕网治疗RA也收效甚佳。对此,笔者提出猜想,中医药或可通过干预中性粒细胞胞外诱捕网改善RA并发动脉粥样硬化。

Epidemiological data indicate that cardiovascular complications plague nearly half of patients with rheumatoid arthritis(RA)and are the leading cause of death in RA patients.This may be related to the fact that RA shares similar pathological features with atherosclerosis,leading to an increased incidence of atherosclerosis in patients with this disease.As a double-edged sword,neutrophil extracellular trap(NET)can both capture pathogens to control disease development and be a pathogen to aggravate the disease.The mediated inflammatory response is the common feature of RA,atherosclerosis,thrombosis,and other diseases.It has been verified that traditional Chinese medicine(TCM)has positive effect on atherosclerosis through a variety of ways,and relevant TCM has achieved satisfactory results in the treatment of RA by regulating the NETs.In this regard,the author proposed that TCM might alleviate RA complicated with atherosclerosis by interfering with the NETs.