摘要
为了探讨炭炒地榆鞣质提取物的壳聚糖PLGA(SCCP)乳液对金黄色葡萄球菌(Staphylococcus aureus,S.aureus)的杀伤作用,用96孔板微量肉汤稀释法测定其对S.aureus的最低抑菌浓度、最小杀菌浓度和联合药敏试验检测抑菌活性。结果显示,与炭炒地榆鞣质提取物相比,SCCP的抑菌活性更强,对S.aureus的最小杀菌浓度为0.063 mg/mL。表明SCCP对S.aureus有较好的抑菌活性,有望开发成新型中药抗菌制剂。
In order to investigate the killing effect of charred Sanguisorba officinalis tannin extracts loading in chitosan PLGA emulsion(SCCP)on Staphylococcus aureus,96-well plate micro broth dilution method was used to determine its minimum inhibitory concentration,minimum bactericidal concentration and combined drug sensitivity test to detect its antibacterial activity.The results showed that compared with the charred Sanguisorba officinalis tannin extracts,SCCP had stronger antibacterial activity,with a minimum bactericidal concentration of 0.063mg/mL.The results indicate that SCCP has good antibacterial activity against S.aureus,so it is expected to be developed into a new and effective antibacterial agent of traditional Chinese medicine.
作者
苏宏芮
李嘉雯
林欣怡
倪泽睿
洪海龙
彭伟龙
伯若楠
SU Hong-rui;LI Jia-wen;LIN Xin-yi;NI Ze-rui;HONG Hai-long;PENG Wei-long;BO Ruo-nan(Collage of Veterinary Medicine,Yangzhou University,Yangzhou,Jiangsu,225009,China;Collaborative Innovation Centre for Prevention and Control of Important Animal Diseases and Zoonoses inJiangsuUniversities,Yangzhou,Jiangsu,225009,China)
出处
《动物医学进展》
北大核心
2024年第8期59-64,共6页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(32002324)
江苏省自然科学基金项目(BK2020945)
扬州大学大学生创新创业训练计划项目(C202211117026Y)
江苏省高校优势学科建设工程资助项目(JS20130601)。
关键词
炭炒地榆鞣质提取物
壳聚糖
PLGA乳液
金黄色葡萄球菌
抑菌活性
charred Sanguisorba officinalis tannin extract
chitosan
PLGA emulsion
Staphylococcus aureus
antibacterial activity
