程控间歇脉冲给药模式在分娩镇痛中的参数研究进展

Research advances in programmed intermittent epidural bolus regimens in labor analgesia

椎管内分娩镇痛是全世界公认的缓解分娩痛最安全、有效的方法。程控间歇硬膜外脉冲给药(PIEB)相较于传统的连续恒速输注(CEI)是更加理想的椎管内分娩镇痛注药模式,但其最佳参数设置目前还没有定论。文章总结和概括目前国内外PIEB的参数(包括脉冲容量、脉冲间隔时间、脉冲速率等)在椎管内分娩镇痛中的应用研究进展,为PIEB更加合理、安全地应用于临床提供参考,也为未来研究者提供和开拓新的思路及新的研究方向。

Neuraxial labor anesthesia is the safest and most effective way to relieve labor pain.Programmed intermittent epidural bolus(PIEB)is considered a more ideal mode of intrathecal labor analgesia drug delivery than the traditional continuous epidural infusion(CEI).However,optimal parameter settings for PIEB have not yet been conclusively determined.This review summarizes and encapsulates the current domestic and international research advances in PIEB parameters set in the application of intrathecal labor analgesia,including bolus volume,inter-bolus interval,infusion rate,and so on.It aims to provide references for better rational and safe clinical application of PIEB and to suggest new perspectives and directions for future researchers.