边缘供体临床应用及保存方法研究进展

Research advances on clinical application and preservation methods of marginal donors

器官移植是终末期器官疾病的有效治疗方式,然而供体器官短缺问题日益突出。边缘供体的运用是目前扩大供体库并缓解临床器官移植供体不足的有效途径之一。因边缘供体本身质量欠佳,故改进边缘供体保存策略,提升其质量并有效应用具有重要临床价值。文章拟对边缘供体(包括心、肺、肝、肾供体器官)的定义、临床应用及其主要保存方法(静态冷藏和机械灌注)研究进展进行综述,旨在提升边缘供体的保存质量及其应用价值。

Organ transplantation is an effective treatment for end-stage organ diseases,however the shortage of donor organs is becoming more and more serious.The application of marginal donors is one of the effective ways to expand the donor pool and alleviate the shortage of donor sources for clinical organ transplantation.Because of the poor quality of the marginal donors themselves,it is of great clinical value to improve the preservation strategy of the marginal donors,enhance their quality,and effectively use them.This review aims to summarize the definition,clinical application,and main preservation methods(static cold storage and machine perfusion)of marginal donor organs(including heart,lung,liver,and kidney),to improve the application value and the preservative quality of marginal donor organs.