益生菌改善老年人肠道菌群失衡相关疾病的研究进展

Research progress of probiotics in improving diseases related to intestinal flora imbalance in the elderly

我国人口的老龄化逐渐成为重要的社会问题。由于肠道菌群失衡所引起的老年人罹患疾病的风险增加,日益受到关注。益生菌可通过竞争黏附位点、调节免疫功能等作用保护肠黏膜并重建肠道菌群结构,从而缓解老年人肠道菌群失衡相关疾病。该文总结了肠道菌群组成随年龄增长的变化、老年人肠道菌群失衡相关疾病及改善途径,重点阐述了近几年益生菌在改善老年人代谢综合征、炎症性肠病、癌症、神经退行性疾病中的研究进展和作用机制,以期为益生菌的合理使用和老年人健康管理和疾病治疗提供理论依据。

The population aging has gradually become an important social problem in our country.The increased risk of diseases in the elderly caused by the imbalance of intestinal flora has attracted more and more attention.Probiotics can protect the intestinal mucosa and reconstruct the structure of intestinal flora by competing for adhesion sites and regulating immune function,so as to alleviate the diseases related to intestinal flora imbalance in the elderly.This article first summarizes the changes in the composition of intestinal flora with aging,the diseases related to intestinal flora imbalance in the elderly,and the ways to improve it,with a focus on the research progress and mechanism of probiotics in improving metabolic syndrome,inflammatory bowel disease,cancer,and neurodegenerative diseases in the elderly in recent years.This study provides a theoretical basis for the rational use of probiotics and the health management and disease treatment of the elderly.