尿常规蛋白尿定性检验在糖尿病肾病临床诊断中的应用

Application of routine proteinuria qualitative test in clinical diagnosis of diabetes nephropathy

目的 探讨尿常规蛋白尿定性检验在糖尿病肾病诊断中的应用价值。方法 选择广东省茂名农垦医院2020年2月—2022年2月收治的54例糖尿病患者作为观察组,以同期在该院参加体检的54例健康体检者作为对照组。对参加研究的人员实施尿常规蛋白尿定性检验,比较两组尿糖、尿微量白蛋白、白细胞、白细胞酯酶的阳性检出率。根据年龄将观察组患者分为<30岁组(7例)、30~60岁组(19例)、> 60岁组(28例),比较不同年龄组糖尿病患者的蛋白尿(尿蛋白+~++和+++)检出情况。结果 观察组尿糖、尿微量白蛋白、白细胞、白细胞酯酶的阳性检出率均显著高于对照组(尿糖:90.91%比0%;尿微量白蛋白:100.00%比3.70%;白细胞:92.59%比9.26%;白细胞酯酶:96.30%比5.56%;均P <0.05)。<30岁组的尿蛋白+~++检出率最高,为57.14%;> 60岁组的尿蛋白+++检出率最高,为89.29%。不同年龄组的尿蛋白+++检出率比较差异有统计学意义。结论 在糖尿病肾病的诊断中应用尿常规蛋白尿定性检验的临床价值较高,且可得出年龄与糖尿病肾病发生具有一定关系的结论。

Objective To explore the application value of urine routine proteinuria qualitative test in diagnosis of diabetic nephropathy.Methods The 54 diabetic patients(observation group)diagnosed and treated in Maoming Agricultural Reclamation Hospital of Guangdong Province in February 2020 to February 2022 were selected,and 54 healthy subjects in the hospital were selected as control group.Urine routine proteinuria qualitative test was performed in the participants in the study,and the positive rates of urine glucose,urine microalbumin,leukocytes and leukocyte esterase were compared between the two groups.According to age,the patients were divided into<30 years old group(7 cases),30-60 years old group(19 cases)and>60 years old group(28 cases).The detection of proteinuria(urinary protein+to++and+++)in patients with diabetes of different age groups was compared.Results The positive rates of urine glucose,urine microalbumin,leukocyte and leukocyte esterase in observation group were higher than those in control group(urine glucose:90.91%vs.0%;urine microalbumin:100.00%vs.3.70%;leukocyte:92.59%vs.9.26%;leukocyte esterase:96.30%vs.5.56%;all P<0.05).The detectable rate of urine protein+to++in<30 years old group was the highest,at 57.14%,and the detectable rate of urinary protein+++in>60 years old group was the highest,at 89.29%.There was a significant difference in detectable rate of urinary protein+++among different age groups.Conclusion In diagnosis of diabetic nephropathy,the clinical application value of urine prescriptive test for proteinuria is high,and age has a certain relationship with the occurrence of diabetic nephropathy.