性激素六项检验在妇科疾病诊断中的应用效果

Application effect of six items for sex hormones in diagnosis of gynecological diseases

目的 探讨性激素六项检验在妇科疾病诊断中的应用效果。方法 采用目的抽样法纳入金乡县人民医院2022年10月—2023年10月收治的90例妇科疾病患者作为观察组,另外选择同期90例健康体检女性作为对照组。对所有研究对象开展性激素六项检验,使用化学发光法检测血清促卵泡激素(FSH)、促黄体素(LH)、雌二醇、睾酮、孕酮、泌乳素(PRL)。比较和分析两组受检者以及不同妇科疾病类型患者的上述指标水平差异。结果 观察组的FSH、LH、睾酮、PRL水平均显著高于对照组[FSH(U/L):29.64±3.05比4.86±1.13;LH(U/L)16.73±2.88比4.69±1.05;睾酮(nmol/L):4.45±0.87比2.08±0.63;PRL(mU/L):526.85±30.89比186.74±25.33;均P <0.05],雌二醇和孕酮水平均显著低于对照组[雌二醇(ng/L):35.15±6.31比179.69±24.26;孕酮(nmol/L):0.99±0.24比3.15±0.73;均P <0.05]。更年期综合征、不孕症、子宫肌瘤、闭经溢乳、功能性出血患者的不同性激素指标水平比较差异均有统计学意义。结论 性激素六项检验对妇科疾病具有良好的诊断效果,能为疾病类型鉴别提供可靠依据,有利于医生制定更确切、有效的治疗方案,对改善预后具有积极作用。

Objective To investigate the application effect of six items for sex hormones in the diagnosis of gynecological diseases.Methods The 90 patients with gynecological diseases admitted to Jinxiang County People's Hospital from October 2022 to October 2023 were selected and included into observation group using purposive sampling method.In addition,90 healthy individuals undergoing physical examinations during the same period were selected and included into control group.The six items for sex hormones test were conducted on all research subjects and chemiluminescence was used to detect serum levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol,testosterone,progesterone and prolactin(PRL).The differences in the levels of the above indicators between two groups of examinees and patients with different types of gynecological diseases were compared and analyzed.Results The levels of FSH,LH,testosterone and PRL in observation group were significantly higher than those in control group[FSH(U/L):29.64±3.05 vs.4.86±1.13;LH(U/L):16.73±2.88 vs.4.69±1.05;testosterone(nmol/L):4.45±0.87 vs.2.08±0.63;PRL(mU/L):526.85±30.89 vs.186.74±25.33;all P<0.05],and the levels of estradiol and progesterone in observation group were significantly lower than those in control group[estradiol(ng/L):35.15±6.31 vs.179.69±24.26;progesterone(nmol/L):0.99±0.24 vs.3.15±0.73;both P<0.05].There were statistically significant differences in hormone levels among patients with menopausal syndrome,infertility,uterine fibroids,amenorrhea and lactation,and functional bleeding.Conclusions Six items of sex hormones test have a good diagnostic effect on gynecological diseases,which could not only be used to diagnose gynecological diseases,but also provide a reliable basis for the differentiation of disease types.The detection is helpful for doctors to formulate more accurate and effective treatment plans and has a positive effect on improving prognosis.