加味五虎汤联合布地奈德混悬液对小儿咳嗽变异性哮喘的疗效研究

Study on the Therapeutic Effect of Modified Wuhu Decoction Combined with Budesonide Suspension in Paediatric Cough Variant Asthma

目的研究加味五虎汤联合布地奈德混悬液治疗小儿咳嗽变异性哮喘的疗效。方法选择2020年1月—2022年12月汕头市中医医院收治的96例咳嗽变异性哮喘患儿作为研究对象,取随机数表法分将其为对照组和观察组,各48例。对照组采用布地奈德混悬液治疗,观察组在对照组治疗基础上联用加味五虎汤治疗。评估两组患者的症状,检测两组患者的用力呼气量占用力肺活量比值(FEV1/FVC)、最大通气量表(MVV)、最大呼气中期流速(MMF)和呼气峰流速(PEF),且检测两组患者的血清白细胞介素-5(IL-5)、基质金属蛋白酶-9(MMP-9)、嗜酸性粒细胞阳离子蛋白(ECP)和IL-8水平。结果治疗后,两组的咳嗽、鼻涕、咽痒、气促、喷嚏和鼻塞症状积分均明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05);治疗后,两组的FEV1/FVC、MVV、MMF和PEF均明显改善,且观察组明显优于对照组,差异有统计学意义(P<0.05);治疗后,两组的血清IL-5、MMP-9、ECP和IL-8水平均明显降低,且观察组明显低于对照组,差异有统计学意义(P<0.05)。结论加味五虎汤联合布地奈德混悬液治疗小儿咳嗽变异性哮喘的疗效显著,能明显改善肺功能和减轻症状,其机制可能与降低血清IL-5、MMP-9、ECP和IL-8水平有关。

Objective To investigate the effect ofmodified Wuhu decoction combined with Budesonide suspension on cough variant asthma in children.Methods Selected 96 cases of patients with cough variant asthma admitted to Shantou Hospital of Traditional Chinese Medicine from January 2020 to December 2022,divided into two groups by taking the randomized numerical table method.The control group was treated with Budesonide suspension,and the observation group was treated with modified Wuhu Decoction.The symptoms of the two groups were evaluated,and the forced expiratory volume to forced Vital capacity ratio(FEV1/FVC),maximum ventilation volume scale(MVV),maximum middle expiratoryflow(MMF)and peak expiratoryflow(PEF)were measured,and the levels of serum interleukin-5(IL-5),matrix metalloproteinase-9(MMP-9),Eosinophil cationic protein(ECP)and IL-8 were measured.Results After treatment,the scores of cough,nasal discharge,throat itching,shortness of breath,sneezing and nasal congestion in both groups were significantly decreased(P<0.05),and the observation group was significantly lower than the control group(P<0.05).After treatment,FEV1/FVC,MVV,MMF and PEF in both groups were significantly improved(P<0.05),and the observation group was significantly better than the control group(P<0.05).After treatment,the serum levels of IL-5,MMP-9,ECP and IL-8 in both groups were significantly decreased(P<0.05),and the observation group was significantly lower than the control group(P<0.05).Conclusion Jiawei Wuhu Decoction combined with Budesonide suspension has a significant effect on cough variant asthma in children,which can significantly improve lung function and relieve symptoms.Its mechanism may be related to the reduction of serum IL-5,MMP-9,ECP and IL-8 levels,which is worth promoting.