鹿瓜多肽注射液对胸腰椎骨折患者骨密度的影响

Effect of Lugua Polypeptide Injection on Bone Mineral Density of Patients with Thoracolumbar Fracture

目的探讨鹿瓜多肽注射液对胸腰椎骨折患者骨密度的影响。方法选取2021年5月—2023年6月在苏州市吴江区第五人民医院就诊的80例胸腰椎骨折患者作为研究对象,所有患者均采用保守治疗方法,使用外固定支具固定,采用随机数表法将其分为观察组(西医常规治疗+鹿瓜多肽注射液,n=40)和对照组(西医常规治疗,n=40)。比较两组骨密度水平、骨代谢指标、腰椎疾患治疗成绩评分表(JOA)评分、视觉模拟评分表(VAS)评分、卧床时间和不良反应发生情况。结果治疗后,两组腰椎骨密度和右股骨颈骨密度水平与治疗前比较均显著升高,且观察组腰椎骨密度和右股骨颈骨密度水平高于对照组,差异有统计学意义(P<0.05)。治疗后,两组甲状旁腺激素、骨钙素和降钙素水平与治疗前比较均不同程度改善,且观察组甲状旁腺激素水平显著高于对照组,骨钙素和降钙素水平均显著低于对照组,差异有统计学意义(P<0.05)。治疗后,两组JOA、VAS评分与治疗前比较,均获得不程度改善,且观察组JOA评分显著高于对照组,VAS评分显著低于对照组,差异有统计学意义(P<0.05)。观察组卧床时间显著短于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论鹿瓜多肽注射液可增加胸腰椎骨折患者的骨密度,调节骨代谢,促进腰椎功能恢复,缓解疼痛,且安全性良好,值得临床应用。

Objective To investigate the effect of Lugua polypeptide injection on bone mineral density in patients with thoracolumbar fractures.Methods 80 patients with thoracolumbar fractures who were treated at the Fifth People's Hospital of Wujiang District,Suzhou City from May 2021 to June 2023 were selected.All patients were treated conservatively andfixed with externalfixators.They were randomly divided into an observation group(conventional Western medicine treatment+deer melon peptide injection,n=40)and a control group(conventional Western medicine treatment,n=40)using a random number table method.The bone mineral density,bone metabolism index,JOA and VAS scores,the bed rest time,and the occurrence of adverse reactions were compared between the two groups.Results After treatment,the bone mineral density of the lumbar vertebrae and the right femoral neck in the two groups were significantly higher than before treatment(P<0.05),and the bone mineral density of the lumbar vertebrae and the right femoral neck in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of parathyroid hormone,osteocalcin and calcitonin in the two groups were improved in different degrees(P<0.05),and the levels of parathyroid hormone in the observation group were significantly higher than those in the control group(P<0.05),while the levels of osteocalcin and calcitonin were significantly lower than those in the control group(P<0.05).After treatment,the JOA and VAS scores of the two groups were not improved to any extent(P<0.05),and the JOA score of the observation group was significantly higher than that of the control group(P<0.05),and the VAS score was significantly lower than that of the control group(P<0.05).The bed rest time in the observation group was significantly shorter than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Lugua polypeptide injection can increase the bone density of patients with thoracolumbar fractures,regulate bone metabolism,promote the recovery of lumbar function and relieve pain,and it is safe and worthy of clinical promotion.