生命全景时空图谱:助力中医药学原理的精准解读

Accurate determination of the meaning and implications of traditional Chinese medicine using panoramic spatiotemporal life atlas

中医药学原理的现代科学解读攸关中医药服务体系的优质高效建设,符合中医药特点的机制全面诠释和优势精准呈现仍然是中医药事业产业现代化国际化变革中迫切需要解决的瓶颈问题.生命全景时空图谱系指采用时空组学作为核心技术,在细胞以及亚细胞分辨率下绘制生命全景分子图谱,整合时间和空间两个维度阐释细胞功能、生命复杂性和人类疾病.近年,被称为“超高分辨率的生命全景照相机”的时空组学技术体系的提出和发展,也为中医药疗效的“说明白、讲清楚”提供新的研究手段和模式策略.具体来说,通过重点关注治疗前后病灶组织的空间位置分布以及时间演进变化信息,分析正常状态、疾病状态甚至疾病不同发展阶段的分子-细胞、细胞-细胞之间和微环境的分布互作情况,能够全面、精准、高效地阐明中医药这类复杂性研究对象的病程演变干预特征和诊治生物学内涵.基于此,本文在总结时空组学技术进展的基础上,进一步提出中医药生命全景时空图谱研究的思路框架和实践路径,旨在从四维水平揭示中医药学防病治病的时空诊疗机理.未来的中医药学原理研究,将尤其重视前沿信息技术的整合与融入,依托生命科学领域的蓬勃发展,优化完善重点领域的方法学和指标体系,解析中医药临床有效性和安全性的科学原理,有的放矢地促进中医药学传承创新发展.

Several areas in the modernization and internationalization of traditional Chinese medicine need to be urgently explored.There is a need for a modern scientific interpretation of the principles and application of traditional Chinese medicine to create a high-quality and efficient medical service system.A comprehensive interpretation of the mechanisms that conform to the characteristics of traditional Chinese medicine and the precise presentation of its advantages are also urgent problems that require solutions.The panoramic spatiotemporal map of life refers to the use of spatiotemporal omics as the core technology to construct a panoramic molecular map of life at cellular and subcellular resolutions.This integrates time and spatial dimensions to explain cell function,life complexity,and human diseases.Recently,the proposal and development of the spatiotemporal omics technology system,known as the“ultrahigh-resolution panoramic camera of life,”has also provided new research methods and model strategies that can be used to explain and clarify the efficacy of traditional Chinese medicine.By focusing on both spatial distribution and temporal evolution of lesion tissues before and after treatment and analyzing normal molecular cells,intercellular interactions,and microenvironment distributions,it is possible to track how these factors change during the disease course as well as different stages of disease development.Consequently,the characteristics of interventions and the diagnostic and therapeutic biological connotations of complex research objects such as traditional Chinese medicine can be comprehensively,accurately,and efficiently elucidated.Using this principle,this article summarized the progress in spatiotemporal omics technology and proposed a framework and practical path for studying the panoramic spatiotemporal map of traditional Chinese medicine.This study aimed to reveal the spatiotemporal diagnosis and treatment mechanism of traditional Chinese medicine in disease prevention and treatment from a four-dimensional perspective.For future research on the principles of traditional Chinese medicine,special attention should be paid to the integration of technologies,specifically cutting-edge information technology.The vigorous development in the field of life science allows the optimization and improvements of methodologies and indicator systems in key areas.This further allows the analysis of scientific principles of the clinical effectiveness and safety of traditional Chinese medicine.Targeted efforts should be made to promote the legacy,innovation,and development of traditional Chinese medicine.