SOD3免疫调节作用的研究进展

New insights into the immunoregulatory role of SOD3

超氧化物歧化酶3(superoxide dismutase 3,SOD3)是一种作用于细胞外的抗氧化酶,其主要功能是催化超氧化物转化为过氧化氢和氧.最近有研究表明,SOD3还参与多种疾病的免疫调节过程.在宿主体内,宿主来源的SOD3直接参与调控氧化应激、免疫细胞的成熟、增殖和分化及炎症反应等免疫调节过程.此外,病原体也可以高表达SOD3逃避宿主免疫防御,并通过抑制宿主的细胞反应以完成入侵过程.SOD3表达水平也与多种免疫相关疾病进展密切相关.因此,SOD3有望成为免疫治疗的关键靶点.本文对SOD3免疫调节作用的研究进展进行了综述.

Superoxide dismutase 3(SOD3)is an antioxidant enzyme that acts outside of cells.Its primary function has been believed to convert superoxide into hydrogen peroxide and oxygen.Recent studies indicated SOD3 also participates in sophisticated immune regulation in diverse diseases.Host-derived SOD3 plays a direct role in modulation of immune processes,including oxidative stress,immune cell maturation,proliferation,differentiation,and inflammation.Pathogens can also express SOD3 to evade host immune defense and facilitate invasion by suppressing host cellular responses.SOD3 expression levels are linked to the progression of immune-related diseases,making it a potential target for immunotherapy.This article thoroughly reviewed the research progress and current knowledge in the immunomodulatory mystery of SOD3.