5⁃羟色胺与帕金森病非运动症状研究进展

Advance on association between 5⁃hydroxytryptamine and non⁃motor symptoms in Parkinson's disease

帕金森病是临床常见的神经系统变性疾病,通常伴有胃肠功能障碍、嗅觉减退、睡眠障碍、抑郁、疼痛和幻觉等非运动症状,严重降低患者生活质量。帕金森病患者存在5⁃羟色胺能神经元退行性变等非多巴胺能系统弥漫性病理改变,且5⁃羟色胺在情绪、认知功能、疼痛等多种神经功能调节方面发挥重要作用,与帕金森病非运动症状密切相关。本文综述5⁃羟色胺与帕金森病非运动症状之间的相关性及其研究进展,以明确帕金森病非运动症状的发病机制,为实现疾病的早期诊断与精准治疗提供理论基础。

Parkinson's disease(PD)is a common neurodegenerative disease in clinical practice.Patients with PD are usually accompanied by non⁃motor symptoms(NMS)such as gastrointestinal dysfunction,hyposmia,sleep disorders,depression,pain and hallucinations,which seriously reduce the quality of life.Recent studies have found that PD patients were accompanied by diffuse pathological changes in non⁃dopaminergic system such as progressive degeneration of 5⁃hydroxytryptamine(5⁃HT)ergic neurons,and 5⁃HT plays an important role in the regulation of emotion,cognitive function,pain and other neural functions,and is closely related to non⁃motor symptoms of PD.This article reviews the correlation between 5⁃HT and non⁃motor symptoms of PD and its research progress,in order to further clarify the pathogenesis of non⁃motor symptoms of PD and provide a theoretical basis for the treatment of PD.