摘要
Glioblastoma(GBM)is the most common primary malignant intracranial tumor with a very poor prognosis.In this study,we systematically analyzed the DNA methylation alterations of autophagy-related lncRNAs and their association with drug therapies in GBM.We identified 9 DNA methylation-dysregulated lncRNA regulators of autophagy-related genes as autophagy-related lncRNAs.A dysregulated regulatory network consisting of 9 autophagy-related lncRNAs and 237 differentially expressed autophagy-related genes was constructed.Identification of small molecule drug candidates that may affect DNA methylation dysregulated lncRNA activity,including 45 drug lncRNA pairs,involving 7 DNA methylation dysregulated lncRNAs and 43 drugs.Furthermore,we identified a DNA methylation-dysregulated autophagy-related lncRNA MIR155HG as an independent prognostic indicator for GBM.
基金
1the University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province,China(No.UNPYSCT-2020174)
the Excellent Youth Project of Provincial Scientific Research Institute(China)(No.CZKYF2022-1-C006)
the Hei Long Jiang Postdoctoral Special Foundation(China)(No.LBH-TZ1018).
