摘要
Glioblastoma multiforme(GBM)is the most malignant intracranial tumor in adults and its unique pathology leads to limited therapeutic benefits.1,2 Mitochondrial fusion and fission play an important role in carcinogenesis;fragmented mitochondria promote tumor cell proliferation and prolonged mitochondria lead to tumor cell apoptosis.3 Therefore,profiling the function and prognostic value of mitochondrial dynamics-related genes(MDRGs)is of great interest for GBM precision treatment.Here we focused on the expression,function,and genetic alterations of MDRGs and identified new DNA methylation sites being significantly associated with the survival of GBM patients using available data in public databases.
基金
the Key R&D Program of the Science and Technology Ministry of China(No.2021YFC2701100)
the National Natural Science Foundation of China(No.82150008,81930036)
the Commission of Science and Technology of Shanghai Municipality,China(No.20JC1418500).
