微调平衡三号方对食管癌调强放疗患者疗效的影响

Effect of fine⁃tuned balance No.3 formula in patients undergoing intensity modulated radiotherapy for esophageal cancer

目的 探讨微调平衡三号方对食管癌调强放疗患者疗效的影响。方法 选择2019年2月至2022年3月江阴市中医院收治的78例食管癌患者,以随机数字表法将其分成研究组与对照组,各39例。2组均接受调强放疗治疗,对照组接受常规肠内营养支持治疗,研究组在对照组的基础上接受微调平衡三号方治疗。2组治疗时间均为3个月。对比2组临床疗效、免疫功能、生存质量(QLQ-C30)量表评分以及不良作用发生率。结果 研究组患者疾病控制率(89.74%)比对照组(71.79%)高(P<0.05)。治疗后,2组患者CD3^(+)、CD8^(+)T淋巴细胞水平均升高(P<0.05),且研究组比对照组高(P<0.05)。治疗后,2组患者CD4^(+)T淋巴细胞、CD4^(+)/CD8^(+)T淋巴细胞水平均降低(P<0.05),且研究组比对照组低(P<0.05)。治疗后,2组QLQ-C30评分均升高(P<0.05),且研究组比对照组高(P<0.05)。2组Ⅰ~Ⅳ级放射性食管炎、消化道反应、骨髓抑制发生率比较差异均无统计学意义(P>0.05)。结论 微调平衡三号方治疗食管癌调强放疗患者疗效确切,可改善患者的免疫功能、生存质量,且安全可靠。

Objective To explore the effect of fine-tuned balance No.3 formula on esophageal cancer patients undergoing intensity modulated radiotherapy.Methods A total of 78 patients with esophageal cancer who were admitted to the Jiangyin Hospital of Traditional Chinese Medicine from February 2019 to March 2022 were enrolled in this study.They were divided into the study group and control group according to random number table,with 39 patients in each group.The patients in both groups received intensity modulated radiotherapy.Then the control group was given routine enteral nutrition support,and the study group also received fine-tuned balance No.3 formula in addition to routine enteral nutrition support.The treatment continued for 3 months.The clinical efficacy,immune function,quality of life scale(QLQ-C30)score and adverse effects were compared between the two groups.Results The disease control rate in the study group was higher than that in the control group(89.74%vs 71.79%,P<0.05).CD3^(+),CD8^(+)and QLQ-C30 score were increased after treatment in both groups(all P<0.05),and these indexes in the study group were significantly higher than those in the control group(all P<0.05).CD4^(+)and CD4^(+)/CD8^(+)were decreased after treatment in both groups(all P<0.05),and these indexes in the study group were significantly lower than those in the control group(all P<0.05).There was no significant difference in the incidences of radiation esophagitis(gradeⅠ-Ⅳ),gastrointestinal reaction or bone marrow suppression between the two groups(P>0.05).Conclusion Fine-tuned balance No.3 formula is safe and effective for the treatment of esophageal cancer patients undergoing intensity modulated radiotherapy.It can improve immune function and quality of life of patients.