DLGAP5在肝细胞癌中的表达及临床意义

Expression of DLGAP5 in hepatocellular carcinoma and its clinical significance

目的:探讨Discs大同源物相关蛋白5(Discs large homolog associated protein 5,DLGAP5)在肝细胞癌(hepatocellular carcinoma,HCC)中的表达及其临床意义。方法:采用免疫组化法检测144对肝细胞癌组织和对应的癌旁组织样本中DLGAP5蛋白的表达,分析其表达与患者临床病理特征的关系,绘制Kaplan-Meier生存曲线分析DLGAP5表达对患者预后的影响。结果:肝细胞癌组织中DLGAP5表达阳性率77.8%,高于癌旁组织的阳性率38.9%,差异有统计学意义(P<0.01)。DLGAP5表达与肿瘤直径、TNM分级、脉管癌栓及肿瘤包膜完整性有关(均P<0.05),而与患者性别、年龄、乙型肝炎表面抗原、肝硬化及远处转移无关(均P>0.05)。Kaplan-Meier生存曲线分析显示,DLGAP5高表达组患者总生存率显著低于DLGAP5低表达组患者,差异具有统计学意义(P<0.05)。结论:DLGAP5蛋白在肝细胞癌中表达增高,其高表达与患者的预后不良有关。

Objective:To investigate the expression of Discs large homolog associated protein 5(DLGAP5)in hepatocellular carcinoma(HCC)and its clinical significance.Methods:The expression of DLGAP5 protein in 144 pairs of hepatocellular carcinoma tissues and corresponding para-carcinoma tissues was detected by immunohistochemical method.The relationship between its expression and clinicopathological features of patients was analyzed.Kaplan-Meier survival curve was drawn to analyze the influence of DLGAP5 expression on prognosis of patients.Results:The positive rate of DLGAP5 expression in hepatocellular carcinoma tissues was 77.8%,which was higher than 38.9%in para-carcinoma tissues,and the difference was statistically significant(P<0.01).DLGAP5 expression was correlated with tumor diameter,TNM stage,vascular thrombus and tumor envelope integrity(P<0.05),but not with gender,age,hepatitis B surface antigen,cirrhosis and distant metastasis(P>0.05).Kaplan-Meier survival curve analysis demonstrated that the overall survival rate of patients with high expression of DLGAP5 was significantly lower than that of patients with low expression of DLGAP5,and the difference was statistically significant(P<0.05).Conclusion:The expression of DLGAP5 protein is increased in HCC,and its high expression is related to the poor prognosis of patients.