导电水凝胶在脊髓损伤修复中应用的研究进展

Applications of conductive hydrogels in repair of spinal cord injury: a review

脊髓损伤是一种严重的中枢神经系统损伤,具有较高的致残率和病死率,严重影响患者的生活质量。目前各种脊髓损伤的治疗方法,如手术、药物和康复等难以实现脊髓的修复、神经功能的改善。电刺激可加速轴突生长和髓鞘形成,促进神经组织修复和再生。可负载电刺激的导电水凝胶在脊髓损伤的治疗中具有较大潜力。在电刺激作用下,不同类型的导电水凝胶各具特性,可发挥多种功能,但临床医师对其在脊髓损伤修复中的应用效果尚缺乏全面认识。为此,笔者就电刺激在脊髓损伤修复中的作用和不同类型导电水凝胶的特性及其在脊髓损伤修复中应用的研究进展进行综述,为用于脊髓损伤修复的导电水凝胶的合成与临床转化提供参考。

Spinal cord injury,a severe injury of the central nervous system,shows high disability and mortality rate and seriously affects the patients′quality of life.It is difficult to restore the spinal cord and achieve satisfactory neurological function improvement with various current treatments for spinal cord injury.Electric stimulation can accelerate axonal growth and myelination and promote nervous tissue repair and regeneration.Conductive hydrogels that can load electric stimulation have great potential in the treatment of spinal cord injuries.Under electric stimulation,different types of conductive hydrogels have different characteristics and can perform a variety of functions.However,clinicians still lack a comprehensive understanding of their application effects in repair of spinal cord injury.To this end,the authors reviewed the research progress on the role of electric stimulation as well as the characteristics and applications of different types of conductive hydrogels in repair of spinal cord injury to provide references for the synthesis and clinical transformation of conductive hydrogels for repair of spinal cord injury.