非编码RNA与人巨细胞病毒潜伏感染关系的研究进展

Research progress on the relationship between non⁃coding RNA and latent infection of human cytomegalovirus

人巨细胞病毒(HCMV)是一种高宿主特异性疱疹病毒,其感染率高、潜伏感染激活后的致病性强。由于目前尚无针对病毒潜伏感染的监测手段,导致HCMV临床诊断困难。近年来有研究报道非编码RNA在疱疹病毒的潜伏感染过程中发挥重要作用,提示可以将HCMV感染相关的特异性非编码RNA应用于病毒潜伏感染期的诊断和监测。本文就与HCMV潜伏感染相关的非编码RNA调控机制作简要综述,进一步阐明非编码RNA与HCMV潜伏感染的关系。

Human cytomegalovirus(HCMV)is a ubiquitous,highly host-specific herpes virus.HCMV poses a significant challenge due to its high infection rate in the human population,strong pathogenic-ity after latent infection reactivation,and the lack of effective monitoring methods for latent infection.Recent studies have shown that non-coding RNA plays an important role in the latent infection of herpes viruses,sug-gesting that the specific expression levels of non-coding RNA can be used to assess the latent infection period of the disease.In this paper,we review the regulatory mechanisms of non-coding RNA related to HCMV latent infection to enhance our understanding.