静息与感染状态下巨噬细胞和经典树突状细胞的发育及功能研究进展

Research advances in the development and function of macrophages and classical dendritic cells during resting and infection

巨噬细胞(MAC)和经典树突状细胞(cDC)是免疫防御的首要防线,在先天免疫和适应性免疫中扮演着重要角色,它们具有高度组织特异性,能够精确的适应环境变化。MAC在维持组织稳态和免疫监视方面发挥作用,而cDC作为最有效的抗原提呈细胞,在免疫应答中起关键作用。这两种细胞类型之间也存在相似性和相互联系,MAC和cDC都能识别病原体和组织损伤,它们通过分泌细胞因子激活其他先天免疫细胞,并通过与T细胞的相互作用启动或调节适应性免疫。本文总结了静息与感染过程中MAC及cDC的发育及功能的研究进展,阐述了它们在免疫系统中的关系和相互作用,为疾病的深入研究提供了理论基础。

Macrophages(MACs)and classical dendritic cells(cDCs)represent the front line of immune defense,playing crucial roles in both innate and adaptive immunity due to their remarkable tissue specificity and precise adaptation to environmental cues.MACs contribute to maintaining tissue homeostasis and immune surveillance,while cDCs function as the most efficient antigen-presenting cells,playing a critical role in immune responses.These two cell types share similarities and interconnections.Both MACs and cDCs are capable of recognizing pathogens and tissue damage,secreting cytokines to activate other innate immune cells,and initiating or modulating adaptive immunity through interactions with T cells.In this review,we provide a comprehensive analysis of the research advances in the development and functions of MACs and cDCs during resting and infection processes,elucidate their interrelationships and interactions within the immune system,and offer a theoretical basis for in-depth studies of diseases.