小续命汤治疗急性风痰瘀阻型大动脉粥样硬化性缺血性脑卒中的疗效

Efficacy of Xiaoxuming Decoction in the Treatment of Acute Large-artery Atherosclerotic Ischemic Stroke of Wind-phlegm and Blood Stasis Type

目的评估小续命汤应用在急性风痰瘀阻型大动脉粥样硬化性缺血性脑卒中(largeartery atherosclerotic ischemic stroke,LAA-IS)患者中的疗效。方法选取2022年1月—2023年7月北京中医医院怀柔医院收治的88例急性风痰瘀阻型LAA-IS患者为研究对象,按照随机数表法分为对照组(44例,给予常规西药治疗)、观察组(44例,加用小续命汤治疗)。比较两组临床有效率、神经损伤标志物、凝血功能。结果与对照组(81.82%)相比,观察组临床总有效率(95.45%)更高,差异有统计学意义(χ^(2)=4.062,P<0.05)。治疗1周后,与对照组比较,观察组S100β蛋白、谷氨酸、神经元特异性烯醇化酶、纤维蛋白原更低,凝血酶原时间、活化部分凝血活酶时间更长,差异有统计学意义(P均<0.05)。结论针对急性风痰瘀阻型LAA-IS患者,小续命汤可以增强整体疗效,调节神经损伤标志物水平,改善凝血功能。

Objective To evaluate the efficacy of Xiaoxuming Decoction in patients with acute windphlegm and blood statis type large-artery atherosclerotic ischemic stroke(LAA-IS).Methods A total of eightyeight patients with acute wind-phlegm and blood statis type LAA-IS in Huairou Hospital of Beijing Hospital of Traditional Chinese Medicine from January 2022 to July 2023 were selected as the study objects and divided into control group(44 cases,given conventional Western medicine treatment)and observation group(44 cases,combined with Xiaoxuming Decoction for treatment)according to random number table method.The clinical response rate,nerve injury markers and coagulation function of two groups were compared.Results Compared with the control group(81.82%),the total clinical effective rate of the observation group(95.45%)was higher,the difference was statistically significant(χ^(2)=4.062,P<0.05).After 1 week of treatment,S100βprotein,glutamate,neuron-specific enolase and fibrinogen were lower in the observation group,prothrombin time and activated part of thromboplastin time were longer compared with the control group,the differences were statistically significant(all P<0.05).Conclusion The application of Xiaoxuming Decoction in LAA-IS patients with acute wind-phlegm and blood statis type can enhance the overall efficacy,adjust the level of nerve injury markers,and improve coagulation function.