麝香保心丸与替罗非班联用治疗急性心肌梗死的效果及对血清ITLN-1,sICAM-1水平的影响

Effect of Shexiang Baoxin Pill Combined with Tirofiban on Acute Myocardial Infarction and Influence of Serum ITLN-1 and SICAM-1 Levels

目的 分析麝香保心丸与替罗非班联用治疗急性心肌梗死(acute myocardial infarction,AMI)的效果及对血清内凝集蛋白-1(intelectin-1,ITLN-1)、可溶性细胞间黏附分子-1(soluble intercelluar adhesion molecule 1,sICAM-1)水平的影响。方法 回顾性选取甘肃省第三人民医院于2021年7月—2023年7月收治的90例AMI患者的临床资料,按照不同用药方式分为对照组(n=45)与观察组(n=45),分别采用替罗非班、麝香保心丸联合替罗非班治疗。比较两组疗效,治疗前后血清ITLN-1,sICAM-1水平,心功能[左室射血分数(left ventricular ejection fractions,LVEF)、左室收缩期内径(left ventricular systolic diameter,LVESD)、左室舒张末期内径(left ventricular end diastolic diameter,LVEDD)]。结果 观察组治疗总有效率(95.56%)高于对照组(82.22%),差异有统计学意义(χ^(2)=4.050,P<0.05)。治疗前,两组血清ITLN-1、sICAM-1、相关心功能指标(LVEF、LVESD、LVEDD)比较,差异无统计学意义(P均>0.05)。治疗后,与对照组比较,观察组ITLN-1更高,sICAM-1水平更低,差异有统计学意义(P均<0.05)。观察组治疗后LVEF高于对照组,LVEDD、LVESD低于对照组,差异有统计学意义(P均<0.05)。结论 麝香保心丸联合替罗非班治疗AMI疗效显著,联合用药能显著提升ITLN-1水平、降低sICAM-1水平、改善患者心功能。

Objective To analyze the curative effect of Shexiang Baoxin pill combined with Tirofiban on acute myocardial infarction (AMI) and the influence of serum intelectin-1 (ITLN-1) and soluble intercelluar adhesion molecule 1 (sICAM-1).Methods The clinical data of ninety patients with AMI admitted to Gansu Province Third People's Hospital from July 2021 to July 2023 were retrospectively selected,and they were divided into control group (n=45,treated with tirofiban) and observation group (n=45,treated with Shexiang Baoxin pill combined with tirofiban) according to different medication methods.The therapeutic effect,serum ITLN-1,sI-CAM-1 levels,cardiac function[left ventricular ejection fraction (LVEF),left ventricular systolic diameter(LVESD),left ventricular end diastolic diameter (LVEDD)]levels before and after treatment of the two groups were compared.Results The total effective rate of the observation group (95.56%) was higher than that of the control group (82.22%),and the difference was statistically significant (χ^(2)=4.050,P<0.05).There were no significant differences in serum ITLN-1,sICAM-1 and related cardiac function indexes (LVEF,LVESD,LVEDD)between the two groups before treatment (all P>0.05).After treatment,ITLN-1 was higher and sICAM-1 level was lower in observation group than those in control group,and the differences were statistically significant(both P<0.05).After treatment,LVEF in observation group was higher than that in control group,LVEDD and LVESD were lower than that in control group,and the differences were statistically significant (all P<0.05).Conclusion Shexiang Baoxin pill combined with tirofiban has significant curative effect in the treatment of AMI,which can significantly increase the level of ITLN-1,reduce the level of sICAM-1 and improve the cardiac function of patients.