米非司酮联合血府逐瘀口服液治疗子宫肌瘤的临床效果

Clinical Effect of Mifepristone Combined with XuefuZhuyu Oral Liquid in the Treatment of Uterine Fibroids

目的 研讨应用米非司酮+血府逐瘀口服液治疗子宫肌瘤的临床效果。方法 随机选取2021年1月—2022年12月济宁市兖州区人民医院收治的80例子宫肌瘤患者为研究对象,按照治疗方法不同分为两组,各40例。对照组予米非司酮治疗,研究组予米非司酮联合血府逐瘀口服液治疗。比较两组病灶改善情况、激素量值、血液流变学量值、不良反应发生情况。结果 研究组总有效率为97.50%,高于对照组的77.50%,差异有统计学意义(χ^(2)=7.314,P=0.006)。治疗前,两组激素量值及血液流变学量值比较,差异无统计学意义(P均>0.05);治疗后,研究组激素量值及血液流变学量值指标均优于对照组,差异有统计学意义(P均<0.05)。治疗后,研究组不良反应发生率(2.50%)高于对照组(0),但差异无统计学意义(χ^(2)=1.012,P=0.314)。结论 子宫肌瘤治疗过程中采用米非司酮联合血府逐瘀口服液能够有效改善患者体内血液流变学与激素水平,改善临床症状,缩小病灶,且用药较为安全。

Objective To study the clinical effect of mifepristone + Xuefu Zhuyu oral liquid in the treatment of uterine fibroids.Methods A total of 80 patients with uterine fibroids admitted to Yanzhou District People's Hospital of Jining City from January 2021 to December 2022 were randomly selected as the study objects,and were randomly divided into two groups with 40 cases each according to different treatment method.The control group was treated with mifepristone,and the study group was treated with mifepristone combined with XuefuZhuyu oral liquid.The improvement of lesion,hormone value,hemorheology value and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 97.50%,which was higher than 77.50% of the control group,and the difference was statistically significant(χ^(2)=7.314,P=0.006).Before treatment,there was no significant difference in hormone and hemorheology between the two groups(both P>0.05).After treatment,the levels of hormone and hemorheology indexes in the study group were better than those in the control group,and the differences were statistically significant(both P<0.05).After treatment,the incidence of adverse reactions in the study group(2.50%) was higher than that in the control group(0),but the difference was not statistically significant(χ^(2)=1.012,P=0.314).Conclusion In the treatment of uterine fibroids,the combination of mifepristone and Xuefuzhuyu oral liquid an effectively improve the hemorheology and hormone level of patients,optimize clinical symptoms,narrow the lesions,and the drug is relatively safe.