探讨沙美特罗替卡松联合异丙托溴铵治疗慢性阻塞性肺疾病的临床有效性

Exploring the Clinical Effectiveness of Salmeterol Fluticasone in Combination with Ipratropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease

目的 研究沙美特罗替卡松联合异丙托溴铵用于治疗慢性阻塞性肺疾病的效果。方法 非随机选取2022年2月—2024年1月盘州市第二人民医院所收治的120例慢性阻塞性肺疾病患者为研究对象,根据不同治疗方法分为单一组与联合组,每组60例。单一组采用沙美特罗替卡松治疗,联合组在此基础上加用异丙托溴铵,对比两组患者的治疗效果、肺功能、不良反应以及血气指标。结果 联合组治疗总有效率为98.33%,高于单一组的83.33%,差异有统计学意义(χ^(2)=8.106,P=0.004)。治疗前,两组用力肺活量(Forced Vital Capacity,FVC)以及第1秒用力呼气容积(Forced Expiratory Volume in the First Second,FEV1)对比,差异无统计学意义(P均>0.05);治疗后,两组FVC、FEV1均升高,且联合组高于单一组,差异有统计学意义(P均<0.05)。单一组不良反应发生率高于联合组,差异有统计学意义(P<0.05)。联合组动脉血氧分压更高,动脉血二氧化碳分压更低,差异有统计学意义(P均<0.05)。结论 异丙托溴铵联合沙美特罗替卡松治疗能改善患者肺功能,减少不良反应,临床效果较高。

Objective To study the effectiveness of salmeterol fluticasone combined with ipratropium bromide for the treatment of chronic obstructive pulmonary disease.Methods 120 patients with chronic obstructive pulmonary disease admitted to Panzhou Second People's Hospital from February 2022 to January 2024 were non-randomly selected as the study subjects,and were divided into a single group and a combined group of 60 cases each by different treatment modalities.The single group was treated with salmeterol fluticasone,and the combined group was treated with ipratropium bromide,and the therapeutic efficacy,lung function,adverse reactions and blood gas indexes of the two groups were compared.Results The total effective rate of treatment in the combined group was 98.33%,which was higher than that of 83.33%in the single group,and the difference was statistically significant (χ^(2)=8.106,P=0.004).Before treatment,compared with forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) in the two groups,the differences were not statistically significant (both P>0.05).After treatment,FVC and FEV1 increased in both groups,and the combined group was higher than the single group,and those in the differences were statistically significant (all P<0.05).The incidence of adverse reactions was higher in the single group than in the combined group,and the differences were statistically significant (P<0.05).The partial pressure of arterial blood oxygen was higher and the partial pressure of arterial blood carbon dioxide was lower in the combined group,and the differences were statistically significant (both P<0.05).Conclusion Ipratropium bromide combined with salmeterol fluticasone treatment can improve patients'lung function,reduce adverse reactions,and the clinical effect is high.