十二井穴刺络放血干预脑梗死的质子磁共振波谱研究

Proton Magnetic Resonance Spectroscopy Study on Twelve Jing Acupoint Bloodletting Puncture Intervention for Cerebral Infarction

目的本研究旨在探究中医十二井穴刺络放血对脑梗死的干预效果,以及其对脑组织代谢的影响,通过质子磁共振波谱技术定量分析。方法选择2019—2022年本院收治的120例患者随机分成两组,将实验组(接受十二井穴刺络放血干预)与对照组(未干预)进行比较。使用质子磁共振波谱技术对脑组织进行扫描,分析能量代谢及N-乙酰天门冬氨酸(NAA)、乳酸(Lac)、胆碱(Cho)等指标的变化。同时,通过神经炎症指标的检测评估炎症反应的变化。结果实验组减轻了脑缺血缺氧损伤,乳酸/丙酮酸比值升高,反映出能量代谢的积极变化。神经炎症指标明显降低,表明十二井穴刺络放血具有抗炎作用。结论十二井穴刺络放血在脑梗死治疗中的潜在作用机制,通过改善脑组织血流、能量代谢以及抑制炎症反应,为中医治疗脑梗死提供了新的理论依据。

Objective To explore intervention effect of traditional Chinese medicine twelve Jing acupoint bloodletting puncture on cerebral infarction and brain tissue metabolism,provide new theoretical basis for treatment of cerebral infarction in traditional Chinese medicine based on quantitative analysis with proton magnetic resonance spectroscopy technology.Methods The paper chose 120 patients from 2019 to 2022,and divided them into two groups randomly:experimental group(with twelve Jing acupoints blood-letting puncture),control group(without intervention).Brain tissue was scanned with proton magnetic resonance spectroscopy technology to analyze changes in energy metabolism and compounds including N-acetylaspartate(NAA),lactate(Lac),and choline(Cho).Meanwhile,changes in inflammatory response were evaluated based on detection of neuroinflammatory indicators.Results Cerebral ischemia and hypoxia injury was less in experimental group,with an increase in lactate/pyruvate ratio,reflecting positive changes in energy metabolism.Significant decrease in neuroinflammatory indicators indicated twelve Jing acupoints bloodletting had anti-inflammatory effect.Conclusion The study preliminarily reveals potential mechanism of twelve Jing acupoints bloodletting in treatment of cerebral infarction,provides new theoretical basis for traditional Chinese medicine treatment of cerebral infarction by improving brain tissue blood flow,energy metabolism,and inhibiting inflammatory reactions.