对比左氧氟沙星三联疗法与阿莫西林三联疗法治疗胃溃疡的临床效果

Clinical Effect Comparison of Levofloxacin Triple Therapy and Amoxicillin Triple Therapy in Treatment of Gastric Ulcers

目的比较左氧氟沙星三联疗法和阿莫西林三联疗法对消化性溃疡疗效的影响。方法选取本院2022年2月—2023年2月收治的74例消化性溃疡患者作为研究对象。根据随机数表方法将患者分成两组,每组37例。A组采用阿莫西林三联疗法治疗,B组采用左氧氟沙星三联疗法治疗。对两组的疗效、炎症因子和总不良反应率进行比较。结果B组总有效率比A组高,组间差异有统计学意义(P<0.05)。A组、B组治疗后的TNF-α浓度、TGF-β浓度、IL-6浓度较治疗前降低,EGF浓度较治疗前升高,组间差异有统计学意义(P<0.05)。对比TNF-α浓度、TGF-β浓度、IL-6浓度,B组更低,对比EGF浓度,B组更高,组间差异有统计学意义(P<0.05)。对比不良反应率,B组更低,组间差异有统计学意义(P<0.05)。结论左氧氟沙星三联疗法治疗消化性溃疡有较好的疗效,其不良反应小,安全性高,可降低炎症反应,具有较好的临床应用价值。

Objective To compare effect of levofloxacin triple therapy and amoxicillin triple therapy on effect of peptic ulcers.Methods The paper chose 74 patients with peptic ulcers in our hospital from February 2022 to February 2023 as research subjects,and divided them into two groups according to random number table method,with 37 cases in each group.Group A was treated with amoxicillin triple therapy,while group B with levofloxacin triple therapy.Curative effect,inflammatory factors,and total adverse reaction rate were compared between two groups.Results Total effective rate of group B was higher than group A(P<0.05).Concentration of TNF-α,TGF-β,IL-6 after treatment in group A and group B was lower than before treatment,while concentration of EGF was higher than before treatment(P<0.05).Concentration of TNF-α,TGF-β,IL-6 was lower in group B(P<0.05),and EGF concentration was higher in group B(P<0.05).Incidence of adverse reactions in group B was lower(P<0.05).Conclusion The triple therapy of levofloxacin can achieve good curative effect on peptic ulcers,with low adverse reactions,high safety,can reduce inflammatory reactions,which has good clinical application value.