阿奇霉素序贯疗法对小儿支原体肺炎的临床疗效及对血清CRP的影响

Clinical Effect of Sequential Therapy with Azithromycin for Children with Mycoplasma Pneumonia and Its Effect on Serum CRP

目的评估阿奇霉素序贯疗法对小儿支原体肺炎的疗效以及对血清CRP的干预作用。方法本次研究对就诊的77例支原体肺炎患儿的资料进行回顾性临床分析,按照诊疗方案的不同分为两组。两组患儿的基础干预均相同,将接受阿奇霉素静脉滴注患者作为对照组(37例),将接受阿奇霉素序贯疗法的患者作为观察组(40例)。两组均以2周为一个用药疗程。评价患儿的临床疗效,干预前及干预1周、干预2周采血测定血清C反应蛋白(CRP)指标。结果对照组有效率低于观察组,组间差异有统计意义(P<0.05)。干预前两组患儿血清CRP水平比较,组间差异无统计意义(P>0.05)。干预1周、干预2周,两组患儿血清CRP水平低于干预前,组间差异有统计意义(P<0.05),并且观察组血清CRP水平的下降程度优于对照组,组间差异有统计意义(P<0.05)。结论阿奇霉素序贯疗法可以进一步提高支原体肺炎患儿的治疗效果,降低促炎症因子分泌,从而减轻症状。

Objective To evaluate application of sequential therapy with azithromycin for children with mycoplasma pneumonia and its intervention effect on serum CRP.Methods The paper reviewed and analyzed medical data of 77 children with mycoplasma pneumonia in the local area.Firstly,it retrieved data of the affected children and divided them into groups according to different diagnosis and treatment,2 groups totally.Basic interventions of two groups of children were the same,37 cases in control group were treated with intravenous infusion of azithromycin,40 children in observation group with sequential therapy with azithromycin.Both groups had a medication course of 2 weeks.Clinical effect of patients was evaluated,serum C-reactive protein(CRP)index by blood collection before intervention,1 week of intervention,and 2 weeks of intervention was detected.Results Effective rate in control group(83.78%)was lower than observation group(97.50%),comparison was statistically significant(P<0.05).Comparison of serum CRP levels between two groups before intervention was not statistically significant(P>0.05).The serum CRP levels between two groups after intervention for 1 week and 2 weeks were lower than before(P<0.05),decrease degree of serum CRP levels in observation group was better than control group,with statistical significance(P<0.05).Conclusion Azithromycin sequential therapy can further improve effect of children with mycoplasma pneumonia,reduce secretion of pro-inflammatory factors,and alleviate symptoms.