基于数据挖掘分析真实世界中医治疗高血压伴失眠用药规律

Analysis of medication rule for treating hypertension with insomnia by TCM in the real world based on data mining

目的:利用数据挖掘技术分析真实世界高血压伴失眠的用药规律。方法:对河南省中西医结合医院治疗高血压伴失眠的143张中药处方进行用药规律分析。结果:共涉及中药118味,频数前5味中药为柴胡、甘草、茯苓、黄芩、天麻。药性多寒、平,五味以甘为主,辛、苦次之;主要归肝经、肺经、心经;药物功效分类中清热、平肝、补气、安神、解表最为常用;常用药对天麻-钩藤、茯苓-半夏等。证型共9种,最常见4种证型分别是痰热内扰型、肝郁化火型、心肾不交型、瘀血内阻型。结论:中医治疗高血压伴失眠重视肝、脾两脏,治法以清热化痰、清热平肝、交通心肾、行气活血安神为主。

Objective:To analyze the medication rules for treating hypertension with insomnia by TCM in the real world based on data mining.Methods:The medication rules of 143 TCM prescriptions for treating hypertension with insomnia in Henan Hospital of Integrated Traditional Chinese and Western Medicine were analyzed.Results:A total of 118 kinds of Chinese herbal medicine were involved,while the top 5 kinds of frequently used Chinese herbal medicine were radix bupleuri,glycyrrhiza,poria cocos,scutellaria baicalensis and gastrodia elata.The herbal properties are mostly cold and peaceful,while the five flavors are mainly sweet,followed by pungent and bitter.The herbal channel-tropism belongs mainly to liver meridian,lung meridian and heart meridian.In the classification of herbal efficacy,clearing heat,calming liver,invigorating qi,tranquilizing mind and relieving exterior syndrome are the most commonly used.Commonly used herbal compatibilities are gastrodia elata-uncaria rhynchophylla,poria cocos-pinellia ternata,etc.There are 9 kinds of syndrome types in total,while four kinds of the most common syndrome types are type of phlegm-heat attacking internally,type of stagnation of liver-qi transforming into fire,type of disharmony of heart-kidney and type of blood-stasis obstructing in the interior.Conclusion:The treatment of hypertension with insomnia by TCM should pay attention to both liver and spleen,while the main methods of treatment are clearing away heat and resolving phlegm,clearing away heat and calming the liver,restoring normal coordination between heart and kidney,activating qi and promoting blood circulation to tranquilize mind.