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替罗非班联合丁苯酞治疗急性进展性脑梗死的疗效及对患者生化指标的影响分析

Curative Effect of Tirofiban Combined with Butylphthalide for Acute Progressive Cerebral Infarction and Its Effect on Biochemical Indicators of Patients
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摘要 目的 探究替罗非班联合丁苯酞在治疗急性进展性脑梗死患者中的应用情况。方法 将本院2022年5月—2023年1月收治的40例急性进展性脑梗死患者随机分为两组,每组20例。对照组采用丁苯酞单药治疗,实验组采用替罗非班+丁苯酞治疗,比较两组患者治疗情况以及对生化指标的影响。结果 治疗后,两组患者的治疗总有效率相比,实验组略高,差异不明显,无统计学意义(P>0.05);与对照组相比,实验组血管内皮生长因子(VEGF)、一氧化氮(NO)以及血红素加氧酶-1(HO-1)水平较低,脑源性神经营养因子(BDNF)水平与认知功能缺损量表(MMSE)评分较高,组间差异显著,具有统计学意义(P<0.05)。结论 在急性进展性脑梗死患者中应用替罗非班联合丁苯酞治疗,可提高治疗有效率,改善生化指标和认知功能,安全有效,值得临床广泛应用。 Objective To explore application of tirofiban combined with butylphthalide in treatment of patients with acute progressive cerebral infarction.Methods The paper chose 40 patients with acute progressive cerebral infarction in our hospital from May 2022 to March 2023,and divided them into two groups randomly,with 20 cases in each group.Control group was treated with single drug of butylphthalide,and experimental group with tirofiban and butylphthalide.Treatment status and biochemical indicators were compared between two groups.Results After treatment,total effective rate in experimental group was slightly higher,difference was not statistically significant(P>0.05).Experimental group had lower levels of vascular endothelial growth factor(VEGF),nitric oxide(NO),and heme oxygenase-1(HO-1),and higher levels of brain-derived neurotrophic factor(BDNF)and cognitive impairment scale(MMSE)scores than control group(P<0.05).Conclusion Tirofiban combined with butylphthalide can improve treatment effect,improve biochemical indicators and cognitive function of patients with acute progressive cerebral infarction,which is safe,effective,and worthy of widespread clinical application.
作者 黄杰静 HUANG Jiejing(Department of Neurology,Guigang City the Second People's Hospital,Guigang,Guigang 537100,Guangxi)
出处 《智慧健康》 2024年第14期29-31,共3页 Smart Healthcare
关键词 替罗非班 丁苯酞 急性进展性脑梗死 生化指标 Tirofiban Butylphthalein Acute progressive cerebral infarction Biochemical indicators
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