苯磺酸氨氯地平联合马来酸依那普利片治疗高血压合并2型糖尿病患者的临床效果观察

Clinical Effect of Amlodipine Besylate Combined with Enalapril Maleate Tablets for Hypertension Patients with Type 2 Diabetes Mellitus

目的 探讨苯磺酸氨氯地平联合马来酸依那普利片治疗合并2型糖尿病的高血压患者的临床效果。方法 选取2021年1月—2022年1月本院收治的合并2型糖尿病的高血压患者160例,根据入院顺序对所有患者进行随机编号,编号奇数纳入观察组,编号偶数纳入对照组,每组各80例。对照组患者接受马来酸依那普利片干预,观察组患者接受苯磺酸氨氯地平联合马来酸依那普利片干预。疗程结束后,对比两组患者血压控制情况、相关生化指标变化情况以及不良反应发生情况。结果 治疗后进行比较,对照组患者血压的两项指标高于观察组患者(P<0.05);观察组的总体降压疗效的有效率高于对照组(P<0.05);治疗后观察组患者的β2-MG低于对照组患者(P<0.05),而Scr和BUN水平差异无统计学意义(P>0.05);对照组的不良反应发生率高于观察组(P>0.05)。结论 对患者使用苯磺酸氨氯地平联合马来酸依那普利片的治疗方案,控制血压的效果显著,且具有保护肾功能的意义。在安全性方面,该治疗方案不会增加不良反应的发生风险,值得临床推广应用。

Objective To investigate clinical effect of amlodipine besylate combined with enalapril maleate tablets in treatment of hypertension patients with type 2 diabetes.Methods The paper chose 160 hypertensive patients with type 2 diabetes from January 2021 to January 2022,and divided them into observation group and control group randomly,with 80 cases in each group.Observation group was treated with intervention of amlodipine besylate combined with enalapril maleate tablets,while control group with intervention of enalapril maleate tablets.After treatment,blood pressure control,changes in relevant biochemical indicators,and incidence of adverse reactions were compared between two groups.Results After different intervention methods,blood pressure indicators decreased in two groups(P<0.05).Further comparison showed,two indicators of control group were higher than observation group after treatment,(P<0.05).Overall effective rate of antihypertensive effect in observation group was 91.25%,higher than 67.50%in control group,(P<0.05).After treatment,three indicators ofβ2-MG,Scr,and BUN decreased in two groups,(P<0.05).After treatment,β2-MG levels in observation group were lower than control group,with statistically significant difference(P<0.05),while there was no statistically significant difference in Scr and BUN levels,(P>0.05).Incidence of adverse reactions was 6.25%in control group and 5.00%in observation group(P>0.05).Conclusion Amlodipine besylate combined with enalapril maleate tablets can achieve significant effect on controlling blood pressure,with protective effect on renal function.In terms of safety,the treatment scheme may not increase risks of muscle adverse reactions,which is worthy of clinical promotion and application.