宫颈癌中p16、Ki67和EGFR的表达及其临床意义

Expression and Clinical Significance of P16,Ki67,and EGFR of Cervical Cancer

目的研究在宫颈癌中p16、Ki67、EFGR的表达与临床意义。方法选取2018年2月—2023年2月常州市肿瘤医院收治的70例宫颈癌患者,通过免疫组织化学染色法检测所有患者的p16、Ki67、EFGR表达情况,并分析其临床意义。结果在收治的70例患者中,p16阳性表达率为48.6%,Ki67阳性表达率为67.1%,EFGR阳性表达率为81.4%;宫颈癌患者体内p16、Ki67和EFGR所呈现出的表达情况同患者在病理层面的分级信息、临床分期信息及淋巴结转移信息密切关联(P<0.05)。结论临床收治的宫颈癌患者p16、Ki67、EFGR所呈现出的表达特征同肿瘤所具有的进展状况及远期预后存在密切关系,其所具有的阳性表达水平特点与病理层面的分级以及临床分期、机体淋巴结转移状况关联性较强。

Objective To study expression and clinical significance of p16,Ki67,and EFGR of cervical cancer.Methods The paper chose 70 cervical cancer patients in Changzhou City Cancer Hospital from February 2018 to February 2023,treated with immunohistochemical staining to detect expression of p16,Ki67,and EFGR,analyzed clinical significance.Results Among the 70 cases,calculation showed,positive expression rate of p16 index was 48.6%,positive expression rate of Ki67 index was 67.1%,positive expression rate of EFGR index was 81.4%.Expression of p16,Ki67,and EFGR of cervical cancer patients was closely related to pathological grading information,clinical staging information,and lymph node metastasis information(P<0.05).Conclusion Expression characteristics of p16,Ki67,and EFGR of cervical cancer patients in clinical practice are closely related to progression and long-term prognosis of the tumor,the positive expression level characteristics are strongly correlated with pathological grading,clinical staging,and lymph node metastasis in the body.