科学—技术—产业关联测度与主题演化规律研究——以生物医药领域为例

Research on the Correlation Measure and Theme Evolution Law of Science-Technology-Industry:Taking the Field of Biomedicine as an Example

[目的/意义]科学、技术、产业之间相互关联,互为促进。特别是在生物医药领域,科学研究与专利技术的紧密关联加速推进了制药产业的创新发展。然而,科学研究、专利技术、药物产品之间如何关联及科学—技术—产业融合主题如何演化尚不明确。[方法/过程]对美国FDA橙皮书官网上的批准药物、药物的关键专利及专利引用的非专利参考文献进行反向引文追踪,从药物—专利—论文引文关系视角分析科学—技术—产业的关联强度与关联速度;基于药物、专利和论文文本建立语料库,利用BERTopic模型进行主题聚类,分析科技产业主题间的关联及其演化。[结果/结论]研究发现,科学关联度与技术关联度均呈逐年上升趋势,而科学—技术的关联速度及技术—产业的关联速度却有逐年下降的趋势;基于科学—技术—产业融合主题及其演化路径,定义6种主题演化模式;在剖析科学—技术—产业发展动力机制基础上,构建科学—技术—产业融合主题发展成熟度的分析框架,发现生物医药领域科学—技术—产业的知识关联与协同驱动可促进科学—技术—产业之间的知识交换,加快新技术的开发和转化,从而推动生物医药产业的创新发展。

[Purpose/Significance]Science,technology and industry are interrelated and mutually reinforcing.Especially in the field of biomedicine,the close relationship between scientific research and patent technology has accelerated the innovation and development of the pharmaceutical industry.However,it is not clear how scientific research,patented technology and innovative drug are linked and how the theme of linkage evolves.[Method/Process]This article conducted reverse citation tracing of approved drugs,key patents of drugs and generic references cited by patents on the US FDA’s Orange Book official web site,and analyzed the evolution of citation structure,strength of associations and speed of associations from the perspective of drug-patent-paper citation relationship.Moreover,it built a corpus based on the texts of drugs,patents,and papers,and performed topic clustering by BERTopic model,and analyzed the associations among topics and their evolution.[Result/conclusion]It finds that the correlation degree of science and technology increased annually,while the correlation speed of science-—technology and the correlation speed of technology-industry decreased year by year.Based on the integrated topic of science-technology-industry and its evolution path,six topic evolution modes are defined.Based on the analysis of the dynamic mechanism of science-technology-industry development,a maturity analysis framework of science-technology-industry integrated topic’s development was constructed.It finds that the knowledge correlation and collaborative driving of science-technology-industry in the biomedical field could promote the knowledge exchange between science-technology-industry,accelerate the development and transformation of new technologies,and thus promote the innovation and development of the biomedical industry.